CASP8 Recombinant Protein
Product Sizes
10ug
£294.00
OPCD01907-10UG
50ug
£576.00
OPCD01907-50UG
200ug
£1053.00
OPCD01907-200UG
About this Product
- SKU:
- OPCD01907
- Additional Names:
- Casp;CASP-8;caspase-8;Fas-linked ICE-like protease;FLI;FLICE;MAC;MACH;Mch5.
- Conjugate:
- Unconjugated
- Concentration:
- 200 ug/mL (prior to lyoph)
- Extra Details:
- Most upstream protease of the activation cascade of caspases responsible for the TNFRSF6/FAS mediated and TNFRSF1A induced cell death. Binding to the adapter molecule FADD recruits it to either receptor. The resulting aggregate called death-inducing signaling complex (DISC) performs CASP8 proteolytic activation. The active dimeric enzyme is then liberated from the DISC and free to activate downstream apoptotic proteases. Proteolytic fragments of the N-terminal propeptide (termed CAP3; CAP5 and CAP6) are likely retained in the DISC. Cleaves and activates CASP3; CASP4; CASP6; CASP7; CASP9 and CASP10. May participate in the GZMB apoptotic pathways. Cleaves ADPRT. Hydrolyzes the small-molecule substrate; Ac-Asp-Glu-Val-Asp-|-AMC. Likely target for the cowpox virus CRMA death inhibitory protein.
- Gene Details:
- caspase 8
- Host:
- E. coli
- Molecular Weight:
- 29.3kDa
- Protein Details:
- Caspase-8
- Purity:
- >95%
- Shipping Conditions:
- Blue Ice
- Source:
- E.coli
- Storage Conditions:
- 2Â[o]C to 8Â[o]C|-80Â[o]C
- Supplier:
- Aviva Systems Biology
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Recombinant Proteins
- Manufacturer's Data Sheet:html_datasheet.php
