BRCA2 Recombinant Protein
Product Sizes
10ug
£283.00
OPCD01716-10UG
50ug
£561.00
OPCD01716-50UG
200ug
£1016.00
OPCD01716-200UG
About this Product
- SKU:
- OPCD01716
- Additional Names:
- BRCA1/BRCA2-containing complex; subunit 2;BRCC2;breast and ovarian cancer susceptibility gene; early onset;breast and ovarian cancer susceptibility protein 2;breast cancer 2 tumor suppressor;breast cancer 2; early onset;breast cancer type 2 susceptibility protein;BROVCA2;FACD;FAD;FAD1;FANCD;FANCD1;Fanconi anemia group D1 protein;GLM3;mutant BRCA2;PNCA2;truncated BRCA2 DNA repair associated;truncated BRCA2 DNA repair-associated protein;truncated breast cancer 2;truncated DNA repair-associated BRCA2;truncated DNA repair-associated protein;XRCC11.
- Conjugate:
- Unconjugated
- Concentration:
- 200 ug/mL (prior to lyoph)
- Extra Details:
- Involved in double-strand break repair and/or homologous recombination. Binds RAD51 and potentiates recombinational DNA repair by promoting assembly of RAD51 onto single-stranded DNA (ssDNA). Acts by targeting RAD51 to ssDNA over double-stranded DNA; enabling RAD51 to displace replication protein-A (RPA) from ssDNA and stabilizing RAD51-ssDNA filaments by blocking ATP hydrolysis. Part of a PALB2-scaffolded HR complex containing RAD51C and which is thought to play a role in DNA repair by HR. May participate in S phase checkpoint activation. Binds selectively to ssDNA; and to ssDNA in tailed duplexes and replication fork structures. May play a role in the extension step after strand invasion at replication-dependent DNA double-strand breaks; together with PALB2 is involved in both POLH localization at collapsed replication forks and DNA polymerization activity. In concert with NPM1; regulates centrosome duplication. Interacts with the TREX-2 complex (transcription and export complex 2) subunits PCID2 and SEM1; and is required to prevent R-loop-associated DNA damage and thus transcription-associated genomic instability. Silencing of BRCA2 promotes R-loop accumulation at actively transcribed genes in replicating and non-replicating cells; suggesting that BRCA2 mediates the control of R-loop associated genomic instability; independently of its known role in homologous recombination (PubMed:24896180).
- Gene Details:
- BRCA2 DNA repair associated
- Host:
- E. coli
- Molecular Weight:
- 32kDa
- Protein Details:
- Breast cancer type 2 susceptibility protein
- Purity:
- > 95%
- Shipping Conditions:
- Blue Ice
- Source:
- E.coli
- Storage Conditions:
- 2Â[o]C to 8Â[o]C|-80Â[o]C
- Supplier:
- Aviva Systems Biology
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Recombinant Proteins
- Manufacturer's Data Sheet:html_datasheet.php
