BLNK Recombinant Protein
Product Sizes
10ug
£272.00
OPCD01651-10UG
50ug
£528.00
OPCD01651-50UG
200ug
£955.00
OPCD01651-200UG
About this Product
- SKU:
- OPCD01651
- Additional Names:
- AGM4;B cell adaptor containing SH2 domain;BASH;bca;B-cell activation;B-cell adapter containing a SH2 domain protein;B-cell adapter containing a Src homology 2 domain protein;B-cell linker protein;BLNK-S;cytoplasmic adapter protein;LY57;SLP65;SLP-65;Src homology [SH2] domain-containing leukocyte protein of 65 kD;Src homology 2 domain-containing leukocyte protein of 65 kDa.
- Conjugate:
- Unconjugated
- Concentration:
- 200 ug/mL (prior to lyoph)
- Extra Details:
- Functions as a central linker protein; downstream of the B-cell receptor (BCR); bridging the SYK kinase to a multitude of signaling pathways and regulating biological outcomes of B-cell function and development. Plays a role in the activation of ERK/EPHB2; MAP kinase p38 and JNK. Modulates AP1 activation. Important for the activation of NF-kappa-B and NFAT. Plays an important role in BCR-mediated PLCG1 and PLCG2 activation and Ca(2+) mobilization and is required for trafficking of the BCR to late endosomes. However; does not seem to be required for pre-BCR-mediated activation of MAP kinase and phosphatidyl-inositol 3 (PI3) kinase signaling. May be required for the RAC1-JNK pathway. Plays a critical role in orchestrating the pro-B cell to pre-B cell transition. May play an important role in BCR-induced B-cell apoptosis.
- Gene Details:
- B cell linker
- Host:
- E. coli
- Molecular Weight:
- 32kDa
- Protein Details:
- B-cell linker protein
- Purity:
- > 95%
- Shipping Conditions:
- Blue Ice
- Source:
- E.coli
- Storage Conditions:
- 2Â[o]C to 8Â[o]C|-80Â[o]C
- Supplier:
- Aviva Systems Biology
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Recombinant Proteins
- Manufacturer's Data Sheet:html_datasheet.php
