BIRC2 Recombinant Protein
Product Sizes
10ug
£268.00
OPCD01641-10UG
50ug
£517.00
OPCD01641-50UG
200ug
£933.00
OPCD01641-200UG
About this Product
- SKU:
- OPCD01641
- Additional Names:
- API1;apoptosis inhibitor 1;baculoviral IAP repeat-containing protein 2;cellular inhibitor of apoptosis 1;cIAP1;c-IAP1;Hiap-2;HIAP2;IAP homolog B;IAP-2;inhibitor of apoptosis protein 2;MIHB;NFR2-TRAF signalling complex protein;RING finger protein 48;RING-type E3 ubiquitin transferase BIRC2;RNF48;TNFR2-TRAF-signaling complex protein 2.
- Conjugate:
- Unconjugated
- Concentration:
- 200 ug/mL (prior to lyoph)
- Extra Details:
- Multi-functional protein which regulates not only caspases and apoptosis; but also modulates inflammatory signaling and immunity; mitogenic kinase signaling; and cell proliferation; as well as cell invasion and metastasis. Acts as an E3 ubiquitin-protein ligase regulating NF-kappa-B signaling and regulates both canonical and non-canonical NF-kappa-B signaling by acting in opposite directions: acts as a positive regulator of the canonical pathway and suppresses constitutive activation of non-canonical NF-kappa-B signaling. The target proteins for its E3 ubiquitin-protein ligase activity include: RIPK1; RIPK2; RIPK3; RIPK4; CASP3; CASP7; CASP8; TRAF2; DIABLO/SMAC; MAP3K14/NIK; MAP3K5/ASK1; IKBKG/NEMO; IKBKE and MXD1/MAD1. Can also function as an E3 ubiquitin-protein ligase of the NEDD8 conjugation pathway; targeting effector caspases for neddylation and inactivation. Acts as an important regulator of innate immune signaling via regulation of Toll-like receptors (TLRs); Nodlike receptors (NLRs) and RIG-I like receptors (RLRs); collectively referred to as pattern recognition receptors (PRRs). Protects cells from spontaneous formation of the ripoptosome; a large multi-protein complex that has the capability to kill cancer cells in a caspase-dependent and caspase-independent manner. Suppresses ripoptosome formation by ubiquitinating RIPK1 and CASP8. Can stimulate the transcriptional activity of E2F1. Plays a role in the modulation of the cell cycle.
- Gene Details:
- baculoviral IAP repeat containing 2
- Host:
- E. coli
- Molecular Weight:
- 58kDa
- Protein Details:
- Baculoviral IAP repeat-containing protein 2
- Purity:
- > 95%
- Shipping Conditions:
- Blue Ice
- Source:
- E.coli
- Storage Conditions:
- 2Â[o]C to 8Â[o]C|-80Â[o]C
- Supplier:
- Aviva Systems Biology
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Recombinant Proteins
- Manufacturer's Data Sheet:html_datasheet.php
