AXIN1 Recombinant Protein
Product Sizes
10ug
£268.00
OPCD01557-10UG
50ug
£522.00
OPCD01557-50UG
200ug
£940.00
OPCD01557-200UG
About this Product
- SKU:
- OPCD01557
- Additional Names:
- AXIN;axin-1;axis inhibition protein 1;axis inhibitor 1;fused; mouse; homolog of;PPP1R49;protein phosphatase 1; regulatory subunit 49.
- Conjugate:
- Unconjugated
- Concentration:
- 200 ug/mL (prior to lyoph)
- Extra Details:
- Component of the beta-catenin destruction complex required for regulating CTNNB1 levels through phosphorylation and ubiquitination; and modulating Wnt-signaling (PubMed:12192039; PubMed:27098453). Controls dorsoventral patterning via two opposing effects; down-regulates CTNNB1 to inhibit the Wnt signaling pathway and ventralize embryos; but also dorsalizes embryos by activating a Wnt-independent JNK signaling pathway (PubMed:12192039). In Wnt signaling; probably facilitates the phosphorylation of CTNNB1 and APC by GSK3B (PubMed:12192039). Likely to function as a tumor suppressor. Enhances TGF-beta signaling by recruiting the RNF111 E3 ubiquitin ligase and promoting the degradation of inhibitory SMAD7 (PubMed:16601693). Also component of the AXIN1-HIPK2-TP53 complex which controls cell growth; apoptosis and development (PubMed:17210684). Facilitates the phosphorylation of TP53 by HIPK2 upon ultraviolet irradiation (PubMed:17210684).
- Gene Details:
- axin 1
- Host:
- E. coli
- Molecular Weight:
- 27kDa
- Protein Details:
- Axin-1
- Purity:
- > 95%
- Shipping Conditions:
- Blue Ice
- Source:
- E.coli
- Storage Conditions:
- 2Â[o]C to 8Â[o]C|-80Â[o]C
- Supplier:
- Aviva Systems Biology
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Recombinant Proteins
- Manufacturer's Data Sheet:html_datasheet.php
