ATM Recombinant Protein
Product Sizes
10ug
£279.00
OPCD01533-10UG
50ug
£543.00
OPCD01533-50UG
200ug
£994.00
OPCD01533-200UG
About this Product
- SKU:
- OPCD01533
- Additional Names:
- AI256621;A-T mutated homolog;ataxia telangiectasia gene mutated in human beings;ataxia telangiectasia mutated homolog;C030026E19Rik;serine-protein kinase ATM.
- Conjugate:
- Unconjugated
- Concentration:
- 200 ug/mL (prior to lyoph)
- Extra Details:
- Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs); apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA); thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]-Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs); thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion; a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and monospecific recognition by the B-cell antigen receptor (BCR) expressed on individual B-lymphocytes. After the introduction of DNA breaks by the RAG complex on one immunoglobulin allele; acts by mediating a repositioning of the second allele to pericentromeric heterochromatin; preventing accessibility to the RAG complex and recombination of the second allele. Also involved in signal transduction and cell cycle control. May function as a tumor suppressor. Necessary for activation of ABL1 and SAPK. Phosphorylates DYRK2; CHEK2; p53/TP53; FANCD2; NFKBIA; BRCA1; CTIP; nibrin (NBN); TERF1; RAD9 and DCLRE1C. May play a role in vesicle and/or protein transport. Could play a role in T-cell development; gonad and neurological function. Binds DNA ends. Plays a role in replication-dependent histone mRNA degradation. Phosphorylation of DYRK2 in nucleus in response to genotoxic stress prevents its MDM2-mediated ubiquitination and subsequent proteasome degradation. Phosphorylates ATF2 which stimulates its function in DNA damage response.
- Gene Details:
- ataxia telangiectasia mutated
- Host:
- E. coli
- Molecular Weight:
- 33.9kDa
- Protein Details:
- Serine-protein kinase ATM
- Purity:
- >95%
- Shipping Conditions:
- Blue Ice
- Source:
- E.coli
- Storage Conditions:
- 2Â[o]C to 8Â[o]C|-80Â[o]C
- Supplier:
- Aviva Systems Biology
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Recombinant Proteins
- Manufacturer's Data Sheet:html_datasheet.php
