ATF4 Recombinant Protein
Product Sizes
10ug
£268.00
OPCD01525-10UG
50ug
£522.00
OPCD01525-50UG
200ug
£940.00
OPCD01525-200UG
About this Product
- SKU:
- OPCD01525
- Additional Names:
- Activating transcription factor 4;Atf-;Atf-4;C/AT;C/ATF;c/EBP-related ATF;cAMP-dependent transcription factor ATF-4;cAMP-responsive element-binding protein 2;CREB;CREB2;CREB-2;cyclic AMP-dependent transcription factor ATF-4;cyclic AMP-responsive element-binding protein 2;TAXREB;TAXREB67;taxREB67 homolog;tax-responsive enhancer element-binding protein 67 homolog.
- Conjugate:
- Unconjugated
- Concentration:
- 200 ug/mL (prior to lyoph)
- Extra Details:
- Transcriptional activator. Binds the cAMP response element (CRE) (consensus: 5'-GTGACGT[AC][AG]-3'); a sequence present in many viral and cellular promoters. Binds to asymmetric CRE's as a heterodimer and to palindromic CRE's as a homodimer. Cooperates with FOXO1 in osteoblasts to regulate glucose homeostasis through suppression of beta-cell production and decrease in insulin production. Regulates the induction of DDIT3/CHOP and asparagine synthetase (ASNS) in response to ER stress. In concert with DDIT3/CHOP; activates the transcription of TRIB3 and promotes ER stress-induced neuronal apoptosis by regulating the transcriptional induction of BBC3/PUMA. Activates transcription of SIRT4. Regulates the circadian expression of the core clock component PER2 and the serotonin transporter SLC6A4. Binds in a circadian time-dependent manner to the cAMP response elements (CRE) in the SLC6A4 and PER2 promoters and periodically activates the transcription of these genes.
- Gene Details:
- activating transcription factor 4
- Host:
- E. coli
- Molecular Weight:
- 22kDa
- Protein Details:
- Cyclic AMP-dependent transcription factor ATF-4
- Purity:
- > 95%
- Shipping Conditions:
- Blue Ice
- Source:
- E.coli
- Storage Conditions:
- 2Â[o]C to 8Â[o]C|-80Â[o]C
- Supplier:
- Aviva Systems Biology
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Recombinant Proteins
- Manufacturer's Data Sheet:html_datasheet.php
