APP Recombinant Protein
Product Sizes
10ug
£283.00
OPCD01452-10UG
50ug
£561.00
OPCD01452-50UG
200ug
£1016.00
OPCD01452-200UG
About this Product
- SKU:
- OPCD01452
- Additional Names:
- A;Abe;Abeta;Abpp;Adap;Ag;alzheimer disease amyloid A4 protein homolog;amyloid beta A4 protein;amyloid precursor protein;amyloid-beta A4 protein;amyloid-beta precursor protein;amyloidogenic glycoprotein;appican;bet;beta-amyloid precursor protein;betaApp;C;Cvap;E030013M08Rik;protease nexin II.
- Conjugate:
- Unconjugated
- Concentration:
- 200 ug/mL (prior to lyoph)
- Extra Details:
- Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth; neuronal adhesion and axonogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions. Can promote transcription activation through binding to APBB1-KAT5 and inhibit Notch signaling through interaction with Numb. Couples to apoptosis-inducing pathways such as those mediated by G(O) and JIP. Inhibits G(o) alpha ATPase activity (By similarity). Acts as a kinesin I membrane receptor; mediating the axonal transport of beta-secretase and presenilin 1. May be involved in copper homeostasis/oxidative stress through copper ion reduction. Can regulate neurite outgrowth through binding to components of the extracellular matrix such as heparin and collagen I and IV (By similarity). The splice isoforms that contain the BPTI domain possess protease inhibitor activity. Induces a AGER-dependent pathway that involves activation of p38 MAPK; resulting in internalization of amyloid-beta peptide and leading to mitochondrial dysfunction in cultured cortical neurons (By similarity). Provides Cu(2+) ions for GPC1 which are required for release of nitric oxide (NO) and subsequent degradation of the heparan sulfate chains on GPC1.
- Gene Details:
- amyloid beta (A4) precursor protein
- Host:
- E. coli
- Molecular Weight:
- 12kDa
- Protein Details:
- Amyloid-beta A4 protein
- Purity:
- > 97%
- Shipping Conditions:
- Blue Ice
- Source:
- E.coli
- Storage Conditions:
- 2Â[o]C to 8Â[o]C|-80Â[o]C
- Supplier:
- Aviva Systems Biology
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Recombinant Proteins
- Manufacturer's Data Sheet:html_datasheet.php
