ANGPT1 Recombinant Protein
Product Sizes
10ug
£268.00
OPCD01296-10UG
50ug
£517.00
OPCD01296-50UG
200ug
£933.00
OPCD01296-200UG
About this Product
- SKU:
- OPCD01296
- Additional Names:
- AGP1;AGPT;ANG1;ANG-1;angiopoietin-1;HAE5.
- Conjugate:
- Unconjugated
- Concentration:
- 200 ug/mL (prior to lyoph)
- Extra Details:
- Binds and activates TEK/TIE2 receptor by inducing its dimerization and tyrosine phosphorylation. Plays an important role in the regulation of angiogenesis; endothelial cell survival; proliferation; migration; adhesion and cell spreading; reorganization of the actin cytoskeleton; but also maintenance of vascular quiescence. Required for normal angiogenesis and heart development during embryogenesis. After birth; activates or inhibits angiogenesis; depending on the context. Inhibits angiogenesis and promotes vascular stability in quiescent vessels; where endothelial cells have tight contacts. In quiescent vessels; ANGPT1 oligomers recruit TEK to cell-cell contacts; forming complexes with TEK molecules from adjoining cells; and this leads to preferential activation of phosphatidylinositol 3-kinase and the AKT1 signaling cascades. In migrating endothelial cells that lack cell-cell adhesions; ANGT1 recruits TEK to contacts with the extracellular matrix; leading to the formation of focal adhesion complexes; activation of PTK2/FAK and of the downstream kinases MAPK1/ERK2 and MAPK3/ERK1; and ultimately to the stimulation of sprouting angiogenesis. Mediates blood vessel maturation/stability. Implicated in endothelial developmental processes later and distinct from that of VEGF. Appears to play a crucial role in mediating reciprocal interactions between the endothelium and surrounding matrix and mesenchyme.
- Gene Details:
- angiopoietin 1
- Host:
- E. coli
- Molecular Weight:
- 28kDa
- Protein Details:
- Angiopoietin-1
- Purity:
- > 95%
- Shipping Conditions:
- Blue Ice
- Source:
- E.coli
- Storage Conditions:
- 2Â[o]C to 8Â[o]C|-80Â[o]C
- Supplier:
- Aviva Systems Biology
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Recombinant Proteins
- Manufacturer's Data Sheet:html_datasheet.php
