AGER Recombinant Protein
Product Sizes
10ug
£261.00
OPCD01184-10UG
50ug
£500.00
OPCD01184-50UG
200ug
£901.00
OPCD01184-200UG
About this Product
- SKU:
- OPCD01184
- Additional Names:
- advanced glycation end-products receptor;advanced glycosylation end product-specific receptor;RA;RAGE;receptor for advanced glycation end-products variant 20;receptor for advanced glycosylation end products.
- Conjugate:
- Unconjugated
- Concentration:
- 200 ug/mL (prior to lyoph)
- Extra Details:
- Mediates interactions of advanced glycosylation end products (AGE). These are nonenzymatically glycosylated proteins which accumulate in vascular tissue in aging and at an accelerated rate in diabetes. Acts as a mediator of both acute and chronic vascular inflammation in conditions such as atherosclerosis and in particular as a complication of diabetes. AGE/RAGE signaling plays an important role in regulating the production/expression of TNF-alpha; oxidative stress; and endothelial dysfunction in type 2 diabetes. Interaction with S100A12 on endothelium; mononuclear phagocytes; and lymphocytes triggers cellular activation; with generation of key proinflammatory mediators. Interaction with S100B after myocardial infarction may play a role in myocyte apoptosis by activating ERK1/2 and p53/TP53 signaling. Can also bind oligonucleotides. Receptor for amyloid beta peptide. Contributes to the translocation of amyloid-beta peptide (ABPP) across the cell membrane from the extracellular to the intracellular space in cortical neurons. ABPP-initiated RAGE signaling; especially stimulation of p38 mitogen-activated protein kinase (MAPK); has the capacity to drive a transport system delivering ABPP as a complex with RAGE to the intraneuronal space. RAGE-dependent signaling in microglia contributes to neuroinflammation; amyloid accumulation; and impaired learning/memory in a mouse model of Alzheimer disease.
- Gene Details:
- advanced glycosylation end product-specific receptor
- Host:
- E. coli
- Molecular Weight:
- 27kDa
- Protein Details:
- Advanced glycosylation end product-specific receptor
- Purity:
- > 95%
- Shipping Conditions:
- Blue Ice
- Source:
- E.coli
- Storage Conditions:
- 2Â[o]C to 8Â[o]C|-80Â[o]C
- Supplier:
- Aviva Systems Biology
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Recombinant Proteins
- Manufacturer's Data Sheet:html_datasheet.php
