ACVR2B Recombinant Protein
Product Sizes
10ug
£257.00
OPCD01074-10UG
50ug
£496.00
OPCD01074-50UG
200ug
£890.00
OPCD01074-200UG
About this Product
- SKU:
- OPCD01074
- Additional Names:
- 4930516B21Rik;Act;activin receptor type IIB;activin receptor type-2B;ActRIIB;AI047905.
- Conjugate:
- Unconjugated
- Concentration:
- 200 ug/mL (prior to lyoph)
- Extra Details:
- Transmembrane serine/threonine kinase activin type-2 receptor forming an activin receptor complex with activin type-1 serine/threonine kinase receptors (ACVR1; ACVR1B or ACVR1c). Transduces the activin signal from the cell surface to the cytoplasm and is thus regulating many physiological and pathological processes including neuronal differentiation and neuronal survival; hair follicle development and cycling; FSH production by the pituitary gland; wound healing; extracellular matrix production; immunosuppression and carcinogenesis. Activin is also thought to have a paracrine or autocrine role in follicular development in the ovary. Within the receptor complex; the type-2 receptors act as a primary activin receptors (binds activin-A/INHBA; activin-B/INHBB as well as inhibin-A/INHA-INHBA). The type-1 receptors like ACVR1B act as downstream transducers of activin signals. Activin binds to type-2 receptor at the plasma membrane and activates its serine-threonine kinase. The activated receptor type-2 then phosphorylates and activates the type-1 receptor. Once activated; the type-1 receptor binds and phosphorylates the SMAD proteins SMAD2 and SMAD3; on serine residues of the C-terminal tail. Soon after their association with the activin receptor and subsequent phosphorylation; SMAD2 and SMAD3 are released into the cytoplasm where they interact with the common partner SMAD4. This SMAD complex translocates into the nucleus where it mediates activin-induced transcription. Inhibitory SMAD7; which is recruited to ACVR1B through FKBP1A; can prevent the association of SMAD2 and SMAD3 with the activin receptor complex; thereby blocking the activin signal. Activin signal transduction is also antagonized by the binding to the receptor of inhibin-B via the IGSF1 inhibin coreceptor (By similarity).
- Gene Details:
- activin receptor IIB
- Host:
- E. coli
- Molecular Weight:
- 17kDa
- Protein Details:
- Activin receptor type-2B
- Purity:
- > 95%
- Shipping Conditions:
- Blue Ice
- Source:
- E.coli
- Storage Conditions:
- 2Â[o]C to 8Â[o]C|-80Â[o]C
- Supplier:
- Aviva Systems Biology
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Recombinant Proteins
- Manufacturer's Data Sheet:html_datasheet.php
