JMJD6 Recombinant Protein
Product Sizes
10ug
£240.00
OPCD00857-10UG
50ug
£446.00
OPCD00857-50UG
200ug
£788.00
OPCD00857-200UG
About this Product
- SKU:
- OPCD00857
- Additional Names:
- arginine demethylase and lysine hydroxylase;bifunctional arginine demethylase and lysyl-hydroxylase JMJD6;histone arginine demethylase JMJD6;jmjC domain-containing protein 6;jumonji domain-containing protein 6;lysyl-hydroxylase JMJD6;peptide-lysine 5-dioxygenase JMJD6;phosphatidylserine receptor;PSR;PTDSR;PTDSR1.
- Conjugate:
- Unconjugated
- Concentration:
- 200 ug/mL (prior to lyoph)
- Extra Details:
- Dioxygenase that can both act as a histone arginine demethylase and a lysyl-hydroxylase. Acts as a lysyl-hydroxylase that catalyzes 5-hydroxylation on specific lysine residues of target proteins such as U2AF2/U2AF65 and LUC7L2. Acts as a regulator of RNA splicing by mediating 5-hydroxylation of U2AF2/U2AF65; affecting the pre-mRNA splicing activity of U2AF2/U2AF65. In addition to peptidyl-lysine 5-dioxygenase activity; may act as an RNA hydroxylase; as suggested by its ability to bind single strand RNA. Also acts as an arginine demethylase which demethylates histone H3 at 'Arg-2' (H3R2me) and histone H4 at 'Arg-3' (H4R3me); thereby playing a role in histone code. However; histone arginine demethylation may not constitute the primary activity in vivo. Has no histone lysine demethylase activity. Required for differentiation of multiple organs during embryogenesis. Acts as a key regulator of hematopoietic differentiation: required for angiogenic sprouting by regulating the pre-mRNA splicing activity of U2AF2/U2AF65. Seems to be necessary for the regulation of macrophage cytokine responses.
- Gene Details:
- jumonji domain containing 6; arginine demethylase and lysine hydroxylase
- Host:
- E. coli
- Molecular Weight:
- 43kDa
- Protein Details:
- Bifunctional arginine demethylase and lysyl-hydroxylase JMJD6
- Purity:
- > 90%
- Shipping Conditions:
- Blue Ice
- Source:
- E.coli
- Storage Conditions:
- 2Â[o]C to 8Â[o]C|-80Â[o]C
- Supplier:
- Aviva Systems Biology
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Recombinant Proteins
- Manufacturer's Data Sheet:html_datasheet.php
