TOP3B Recombinant Protein
Product Sizes
10ug
£246.00
OPCD00469-10UG
50ug
£463.00
OPCD00469-50UG
200ug
£825.00
OPCD00469-200UG
About this Product
- SKU:
- OPCD00469
- Additional Names:
- DNA topoisomerase 3-beta-1;DNA topoisomerase III beta-1;TOP3B1;topoisomerase (DNA) III beta;topoisomerase III beta.
- Conjugate:
- Unconjugated
- Concentration:
- 200 ug/mL (prior to lyoph)
- Extra Details:
- Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme; resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand than undergoes passage around the unbroken strand thus removing DNA supercoils. Finally; in the religation step; the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity). Possesses negatively supercoiled DNA relaxing activity.
- Gene Details:
- DNA topoisomerase III beta
- Host:
- E. coli
- Molecular Weight:
- 32kDa
- Protein Details:
- DNA topoisomerase 3-beta-1
- Purity:
- > 90%
- Shipping Conditions:
- Blue Ice
- Source:
- E.coli
- Storage Conditions:
- 2Â[o]C to 8Â[o]C|-80Â[o]C
- Supplier:
- Aviva Systems Biology
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Recombinant Proteins
- Manufacturer's Data Sheet:html_datasheet.php
