ALOX12B Recombinant Protein
Product Sizes
10ug
£235.00
OPCD00369-10UG
50ug
£435.00
OPCD00369-50UG
200ug
£766.00
OPCD00369-200UG
About this Product
- SKU:
- OPCD00369
- Additional Names:
- 12R-lipoxygenase;12R-LOX;arachidonate 12-lipoxygenase; 12R-type;ARCI2;epidermis-type lipoxygenase 12.
- Conjugate:
- Unconjugated
- Concentration:
- 200 ug/mL (prior to lyoph)
- Extra Details:
- Non-heme iron-containing dioxygenase that catalyzes the stereo-specific peroxidation of free and esterified polyunsaturated fatty acids generating a spectrum of bioactive lipid mediators. Mainly converts arachidonic acid to (12R)-hydroperoxyeicosatetraenoic acid/(12R)-HPETE and minor stereoisomers. In the skin; acts upstream of ALOXE3 on the lineolate moiety of esterified omega-hydroxyacyl-sphingosine (EOS) ceramides to produce an epoxy-ketone derivative; a crucial step in the conjugation of omega-hydroxyceramide to membrane proteins. Therefore plays a crucial role in the synthesis of corneocytes lipid envelope and the establishment of the skin barrier to water loss. May also play a role in the regulation of the expression of airway mucins.
- Gene Details:
- arachidonate 12-lipoxygenase; 12R type
- Host:
- E. coli
- Molecular Weight:
- 30kDa
- Protein Details:
- Arachidonate 12-lipoxygenase; 12R-type
- Purity:
- > 90%
- Shipping Conditions:
- Blue Ice
- Source:
- E.coli
- Storage Conditions:
- 2Â[o]C to 8Â[o]C|-80Â[o]C
- Supplier:
- Aviva Systems Biology
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Recombinant Proteins
- Manufacturer's Data Sheet:html_datasheet.php
