Recombinant SARS-CoV-2 Spike Glycoprotein
Product Sizes
100ug
£528.00
OPCA335987-100UG
1mg
£1920.00
OPCA335987-1MG
About this Product
- SKU:
- OPCA335987
- Additional Names:
- E2;GU280_gp02;Peplomer protein;spike glycoprotein;surface glycoprotein.
- Concentration:
- Varies by lot. See vial for concentration.
- Extra Details:
- Attaches the virion to the cell membrane by interacting with host receptor; initiating the infection. Binding to human ACE2 receptor and internalization of the virus into the endosomes of the host cell induces conformational changes in the Spike glycoprotein (PubMed:32142651; PubMed:32221306; PubMed:32075877; PubMed:32155444). Binding to host NRP1 and NRP2 via C-terminal polybasic sequence enhances virion entry into host cell (PubMed:33082294; PubMed:33082293). This interaction may explain virus tropism of human olfactory epithelium cells; which express high level of NRP1 and NRP2 but low level of ACE2 (PubMed:33082293). The stalk domain of S contains three hinges; giving the head unexpected orientational freedom (PubMed:32817270). Uses human TMPRSS2 for priming in human lung cells which is an essential step for viral entry (PubMed:32142651). Can be alternatively processed by host furin (PubMed:32362314). Proteolysis by cathepsin CTSL may unmask the fusion peptide of S2 and activate membrane fusion within endosomes.
- Gene Details:
- surface glycoprotein
- Molecular Weight:
- 38.2 kDa
- Protein Details:
- Spike glycoprotein
- Purity:
- Greater than 85% as determined by SDS-PAGE.
- Purification:
- Affinity purified using IMAC
- Shipping Conditions:
- Blue Ice
- Source:
- Yeast
- Storage Conditions:
- -20Â[o]C or -80Â[o]C
- Supplier:
- Aviva Systems Biology
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Recombinant Proteins
- Manufacturer's Data Sheet:html_datasheet.php
