HSP90AA1 Recombinant Protein
Product Sizes
20ug
£550.00
OPCA05419-20UG
100ug
£1356.00
OPCA05419-100UG
About this Product
- SKU:
- OPCA05419
- Additional Names:
- 90-kDa heat shock protein;heat shock protein HSP 90-alpha;HSP90;Hspca.
- Extra Details:
- Molecular chaperone that promotes the maturation; structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity which is essential for its chaperone activity. This cycle probably induces conformational changes in the client proteins; thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition; ATPase cycle and chaperone function. Engages with a range of client protein classes via its interaction with various co-chaperone proteins or complexes; that act as adapters; simultaneously able to interact with the specific client and the central chaperone itself. Recruitment of ATP and co-chaperone followed by client protein forms a functional chaperone. After the completion of the chaperoning process; properly folded client protein and co-chaperone leave HSP90 in an ADP-bound partially open conformation and finally; ADP is released from HSP90 which acquires an open conformation for the next cycle. Apart from its chaperone activity; it also plays a role in the regulation of the transcription machinery. HSP90 and its co-chaperones modulate transcription at least at three different levels. In the first place; they alter the steady-state levels of certain transcription factors in response to various physiological cues. Second; they modulate the activity of certain epigenetic modifiers; such as histone deacetylases or DNA methyl transferases; and thereby respond to the change in the environment. Third; they participate in the eviction of histones from the promoter region of certain genes and thereby turn on gene expression. Binds bacterial lipopolysaccharide (LPS) and mediates LPS-induced inflammatory response; including TNF secretion by monocytes. Interacts with HECTD1 (via N-terminus) (By similarity).
- Gene Details:
- heat shock protein 90 alpha family class A member 1
- Molecular Weight:
- 19.7 kDa
- Protein Details:
- Heat shock protein HSP 90-alpha
- Purity:
- Greater than 90% as determined by SDS-PAGE.
- Shipping Conditions:
- Blue Ice
- Source:
- Baculovirus
- Storage Conditions:
- -20Â[o]C or -80Â[o]C
- Supplier:
- Aviva Systems Biology
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Recombinant Proteins
- Manufacturer's Data Sheet:html_datasheet.php
