TARBP2 Recombinant Protein
Product Sizes
20ug
£348.00
OPCA04838-20UG
100ug
£500.00
OPCA04838-100UG
1mg
£1822.00
OPCA04838-1MG
About this Product
- SKU:
- OPCA04838
- Additional Names:
- LOQS;RISC-loading complex subunit TARBP2;TAR (HIV) RNA-binding protein 2;TAR (HIV) RNA-binding protein TRBP1;TAR (HIV-1) RNA binding protein 2;TAR RNA binding protein 2;TAR RNA-binding protein 2;TARBP2; RISC loading complex RNA binding subunit;trans-activation responsive RNA-binding protein;Trans-activation-responsive RNA-binding protein;TRBP;TRBP1;TRBP2.
- Extra Details:
- Required for formation of the RNA induced silencing complex (RISC). Component of the RISC loading complex (RLC); also known as the micro-RNA (miRNA) loading complex (miRLC); which is composed of DICER1; AGO2 and TARBP2. Within the RLC/miRLC; DICER1 and TARBP2 are required to process precursor miRNAs (pre-miRNAs) to mature miRNAs and then load them onto AGO2. AGO2 bound to the mature miRNA constitutes the minimal RISC and may subsequently dissociate from DICER1 and TARBP2. May also play a role in the production of short interfering RNAs (siRNAs) from double-stranded RNA (dsRNA) by DICER1. Binds to the HIV-1 TAR RNA which is located in the long terminal repeat (LTR) of HIV-1; and stimulates translation of TAR-containing RNAs. This is achieved in part at least by binding to and inhibiting EIF2AK2/PKR; thereby reducing phosphorylation and inhibition of EIF2S1/eIF-2-alpha. May also promote translation of TAR-containing RNAs independently of EIF2AK2/PKR.
- Gene Details:
- TARBP2 subunit of RISC loading complex
- Molecular Weight:
- 66 kDa
- Protein Details:
- RISC-loading complex subunit TARBP2
- Purity:
- Greater than 90% as determined by SDS-PAGE.
- Shipping Conditions:
- Blue Ice
- Source:
- E.coli
- Storage Conditions:
- -20Â[o]C or -80Â[o]C
- Supplier:
- Aviva Systems Biology
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Recombinant Proteins
- Manufacturer's Data Sheet:html_datasheet.php
