SIRT6 Recombinant Protein
Product Sizes
20ug
£348.00
OPCA04794-20UG
100ug
£500.00
OPCA04794-100UG
1mg
£1822.00
OPCA04794-1MG
About this Product
- SKU:
- OPCA04794
- Additional Names:
- NAD-dependent protein deacetylase sirtuin-6;regulatory protein SIR2 homolog 6;SIR2L6;SIR2-like protein 6;sir2-related protein type 6;sirtuin type 6.
- Extra Details:
- NAD-dependent protein deacetylase. Has deacetylase activity towards histone H3K9Ac and H3K56Ac. Modulates acetylation of histone H3 in telomeric chromatin during the S-phase of the cell cycle. Deacetylates histone H3K9Ac at NF-kappa-B target promoters and may down-regulate the expression of a subset of NF-kappa-B target genes. Acts as a corepressor of the transcription factor HIF1A to control the expression of multiple glycolytic genes to regulate glucose homeostasis. Required for genomic stability. Regulates the production of TNF protein. Has a role in the regulation of life span (By similarity). Deacetylation of nucleosomes interferes with RELA binding to target DNA. May be required for the association of WRN with telomeres during S-phase and for normal telomere maintenance. Required for genomic stability. Required for normal IGF1 serum levels and normal glucose homeostasis. Modulates cellular senescence and apoptosis. On DNA damage; promotes DNA end resection via deacetylation of RBBP8. Has very weak deacetylase activity and can bind NAD(+) in the absence of acetylated substrate.
- Gene Details:
- sirtuin 6
- Molecular Weight:
- 66 kDa
- Protein Details:
- NAD-dependent protein deacetylase sirtuin-6
- Purity:
- Greater than 90% as determined by SDS-PAGE.
- Shipping Conditions:
- Blue Ice
- Source:
- E.coli
- Storage Conditions:
- -20Â[o]C or -80Â[o]C
- Supplier:
- Aviva Systems Biology
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Recombinant Proteins
- Manufacturer's Data Sheet:html_datasheet.php
