S100A12 Recombinant Protein
Product Sizes
20ug
£348.00
OPCA04755-20UG
100ug
£500.00
OPCA04755-100UG
1mg
£1822.00
OPCA04755-1MG
About this Product
- SKU:
- OPCA04755
- Additional Names:
- CAAF1;CAGC;calcitermin;calcium-binding protein in amniotic fluid 1;calgranulin C;Calgranulin-C;CGRP;ENRAGE;EN-RAGE;extracellular newly identified RAGE-binding protein;migration inhibitory factor-related protein 6;MRP6;MRP-6;neutrophil S100 protein;p6;protein S100-A12;S100 calcium-binding protein A12.
- Extra Details:
- S100A12 is a calcium-; zinc- and copper-binding protein which plays a prominent role in the regulation of inflammatory processes and immune response. Its proinflammatory activity involves recruitment of leukocytes; promotion of cytokine and chemokine production; and regulation of leukocyte adhesion and migration. Acts as an alarmin or a danger associated molecular pattern (DAMP) molecule and stimulates innate immune cells via binding to receptor for advanced glycation endproducts (AGER). Binding to AGER activates the MAP-kinase and NF-kappa-B signaling pathways leading to production of proinflammatory cytokines and up-regulation of cell adhesion molecules ICAM1 and VCAM1. Acts as a monocyte and mast cell chemoattractant. Can stimulate mast cell degranulation and activation which generates chemokines; histamine and cytokines inducing further leukocyte recruitment to the sites of inflammation. Can inhibit the activity of matrix metalloproteinases; MMP2; MMP3 and MMP9 by chelating Zn(2+) from their active sites. Possesses filariacidal and filariastatic activity. Calcitermin possesses antifungal activity against C.albicans and is also active against E.coli and P.aeruginosa but not L.monocytogenes and S.aureus.
- Gene Details:
- S100 calcium binding protein A12
- Molecular Weight:
- 37.4 kDa
- Protein Details:
- Protein S100-A12
- Purity:
- Greater than 90% as determined by SDS-PAGE.
- Shipping Conditions:
- Blue Ice
- Source:
- E.coli
- Storage Conditions:
- -20Â[o]C or -80Â[o]C
- Supplier:
- Aviva Systems Biology
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Recombinant Proteins
- Manufacturer's Data Sheet:html_datasheet.php
