APOBEC3C Recombinant Protein
Product Sizes
20ug
£463.00
OPCA04720-20UG
100ug
£652.00
OPCA04720-100UG
1mg
£2446.00
OPCA04720-1MG
About this Product
- SKU:
- OPCA04720
- Additional Names:
- A3C;APOBEC1L;APOBEC1-like;apolipoprotein B editing enzyme catalytic polypeptide-like 3C;apolipoprotein B mRNA editing enzyme; catalytic polypeptide-like 3C;ARDC2;ARDC4;ARP5;bK150C2.3;DNA dC->dU-editing enzyme APOBEC-3C;PBI;phorbolin I;probable DNA dC->dU-editing enzyme APOBEC-3C.
- Extra Details:
- DNA deaminase (cytidine deaminase) which acts as an inhibitor of retrovirus replication and retrotransposon mobility via deaminase-dependent and -independent mechanisms. After the penetration of retroviral nucleocapsids into target cells of infection and the initiation of reverse transcription; it can induce the conversion of cytosine to uracil in the minus-sense single-strand viral DNA; leading to G-to-A hypermutations in the subsequent plus-strand viral DNA. The resultant detrimental levels of mutations in the proviral genome; along with a deamination-independent mechanism that works prior to the proviral integration; together exert efficient antiretroviral effects in infected target cells. Selectively targets single-stranded DNA and does not deaminate double-stranded DNA or single-or double-stranded RNA. Exhibits antiviral activity against simian immunodeficiency virus (SIV); hepatitis B virus (HBV); herpes simplex virus 1 (HHV-1) and Epstein-Barr virus (EBV) and may inhibit the mobility of LTR and non-LTR retrotransposons. May also play a role in the epigenetic regulation of gene expression through the process of active DNA demethylation.
- Gene Details:
- apolipoprotein B mRNA editing enzyme catalytic subunit 3C
- Molecular Weight:
- 49.8 kDa
- Protein Details:
- DNA dC->dU-editing enzyme APOBEC-3C
- Purity:
- Greater than 90% as determined by SDS-PAGE.
- Shipping Conditions:
- Blue Ice
- Source:
- E.coli
- Storage Conditions:
- -20Â[o]C or -80Â[o]C
- Supplier:
- Aviva Systems Biology
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Recombinant Proteins
- Manufacturer's Data Sheet:html_datasheet.php
