LMP2 Recombinant Protein
Product Sizes
20ug
£615.00
OPCA04672-20UG
100ug
£886.00
OPCA04672-100UG
About this Product
- SKU:
- OPCA04672
- Additional Names:
- HHV4_LMP-2A;HHV4_LMP-2B;membrane protein LMP-2A;membrane protein LMP-2B;Terminal protein.
- Extra Details:
- Isoform LMP2A maintains EBV latent infection of B-lymphocyte; by preventing lytic reactivation of the virus in response to surface immunoglobulin (sIg) cross-linking. Acts like a dominant negative inhibitor of the sIg-associated protein tyrosine kinases; LYN and SYK. Also blocks translocation of the B-cell antigen receptor (BCR) into lipid rafts; preventing the subsequent signaling and accelerated internalization of the BCR upon BCR cross-linking. Serves as a molecular scaffold to recruit SYK; LYN and E3 protein-ubiquitin ligases; such as ITCH and NEDD4L; leading to ubiquitination and potential degradation of both tyrosines kinases. Possesses a constitutive signaling activity in non-transformed cells; inducing bypass of normal B lymphocyte developmental checkpoints allowing immunoglobulin-negative cells to colonize peripheral lymphoid organs.
- Gene Details:
- membrane protein LMP-2A|membrane protein LMP-2B
- Molecular Weight:
- 17.6 kDa
- Protein Details:
- Latent membrane protein 2
- Purity:
- Greater than 90% as determined by SDS-PAGE.
- Shipping Conditions:
- Blue Ice
- Source:
- Yeast
- Storage Conditions:
- -20Â[o]C or -80Â[o]C
- Supplier:
- Aviva Systems Biology
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Recombinant Proteins
- Manufacturer's Data Sheet:html_datasheet.php
