RUNX3 Recombinant Protein
Product Sizes
20ug
£348.00
OPCA04548-20UG
100ug
£500.00
OPCA04548-100UG
1mg
£1822.00
OPCA04548-1MG
About this Product
- SKU:
- OPCA04548
- Additional Names:
- acute myeloid leukemia 2 protein;acute myeloid leukemia gene 2;AML2;CBFA3;CBF-alpha-3;core-binding factor subunit alpha-3;core-binding factor; runt domain; alpha subunit 3;oncogene AML-2;PEA2 alpha C;PEBP2 alpha C;PEBP2aC;polyomavirus enhancer-binding protein 2 alpha C subunit;runt related transcription factor 3;runt-related transcription factor 3;SL3/AKV core-binding factor alpha C subunit;SL3-3 enhancer factor 1 alpha C subunit;transcription factor AML2.
- Extra Details:
- Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'-TGTGGT-3'; or very rarely; 5'-TGCGGT-3'; within their regulatory regions via their runt domain; while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX. The heterodimers bind to the core site of a number of enhancers and promoters; including murine leukemia virus; polyomavirus enhancer; T-cell receptor enhancers; LCK; IL3 and GM-CSF promoters (By similarity). May be involved in the control of cellular proliferation and/or differentiation. In association with ZFHX3; upregulates CDKN1A promoter activity following TGF-beta stimulation (PubMed:20599712). CBF complexes repress ZBTB7B transcription factor during cytotoxic (CD8+) T cell development. They bind to RUNX-binding sequence within the ZBTB7B locus acting as transcriptional silencer and allowing for cytotoxic T cell differentiation. CBF complexes binding to the transcriptional silencer is essential for recruitment of nuclear protein complexes that catalyze epigenetic modifications to establish epigenetic ZBTB7B silencing (By similarity).
- Gene Details:
- RUNX family transcription factor 3
- Molecular Weight:
- 49.4 kDa
- Protein Details:
- Runt-related transcription factor 3
- Purity:
- Greater than 90% as determined by SDS-PAGE.
- Shipping Conditions:
- Blue Ice
- Source:
- E.coli
- Storage Conditions:
- -20Â[o]C or -80Â[o]C
- Supplier:
- Aviva Systems Biology
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Recombinant Proteins
- Manufacturer's Data Sheet:html_datasheet.php
