CD3G Recombinant Protein
Product Sizes
20ug
£615.00
OPCA04417-20UG
100ug
£886.00
OPCA04417-100UG
About this Product
- SKU:
- OPCA04417
- Additional Names:
- CD3 gamma;CD3g molecule; epsilon (CD3-TCR complex);CD3g molecule; gamma (CD3-TCR complex);T-cell receptor T3 gamma chain;T-cell surface glycoprotein CD3 gamma chain.
- Extra Details:
- Part of the TCR-CD3 complex present on T-lymphocyte cell surface that plays an essential role in adaptive immune response. When antigen presenting cells (APCs) activate T-cell receptor (TCR); TCR-mediated signals are transmitted across the cell membrane by the CD3 chains CD3D; CD3E; CD3G and CD3Z. All CD3 chains contain immunoreceptor tyrosine-based activation motifs (ITAMs) in their cytoplasmic domain. Upon TCR engagement; these motifs become phosphorylated by Src family protein tyrosine kinases LCK and FYN; resulting in the activation of downstream signaling pathways. In addition to this role of signal transduction in T-cell activation; CD3G plays an essential role in the dynamic regulation of TCR expression at the cell surface. Indeed; constitutive TCR cycling is dependent on the di-leucine-based (diL) receptor-sorting motif present in CD3G.
- Gene Details:
- CD3g molecule
- Molecular Weight:
- 12.5 kDa
- Protein Details:
- T-cell surface glycoprotein CD3 gamma chain
- Purity:
- Greater than 90% as determined by SDS-PAGE.
- Shipping Conditions:
- Blue Ice
- Source:
- Yeast
- Storage Conditions:
- -20Â[o]C or -80Â[o]C
- Supplier:
- Aviva Systems Biology
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Recombinant Proteins
- Manufacturer's Data Sheet:html_datasheet.php
