MDC1 Recombinant Protein
Product Sizes
20ug
£532.00
OPCA04285-20UG
100ug
£760.00
OPCA04285-100UG
About this Product
- SKU:
- OPCA04285
- Additional Names:
- homologue to Drosophila photoreceptor protein calphotin;mediator of DNA damage checkpoint protein 1;NFBD1;nuclear factor with BRCT domains 1.
- Extra Details:
- Required for checkpoint mediated cell cycle arrest in response to DNA damage within both the S phase and G2/M phases of the cell cycle. May serve as a scaffold for the recruitment of DNA repair and signal transduction proteins to discrete foci of DNA damage marked by 'Ser-139' phosphorylation of histone H2AFX. Also required for downstream events subsequent to the recruitment of these proteins. These include phosphorylation and activation of the ATM; CHEK1 and CHEK2 kinases; and stabilization of TP53 and apoptosis. ATM and CHEK2 may also be activated independently by a parallel pathway mediated by TP53BP1.
- Gene Details:
- mediator of DNA damage checkpoint 1
- Molecular Weight:
- 22.9 kDa
- Protein Details:
- Mediator of DNA damage checkpoint protein 1
- Purity:
- Greater than 90% as determined by SDS-PAGE.
- Shipping Conditions:
- Blue Ice
- Source:
- Yeast
- Storage Conditions:
- -20Â[o]C or -80Â[o]C
- Supplier:
- Aviva Systems Biology
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Recombinant Proteins
- Manufacturer's Data Sheet:html_datasheet.php
