ASPN Recombinant Protein
Product Sizes
20ug
£463.00
OPCA04221-20UG
100ug
£652.00
OPCA04221-100UG
1mg
£2446.00
OPCA04221-1MG
About this Product
- SKU:
- OPCA04221
- Additional Names:
- asporin;asporin (LRR class 1);asporin proteoglycan;OS3;periodontal ligament associated protein 1;Periodontal ligament-associated protein 1;PLAP1;PLAP-1;SLRR1C;small leucine-rich protein 1C.
- Extra Details:
- Negatively regulates periodontal ligament (PDL) differentiation and mineralization to ensure that the PDL is not ossified and to maintain homeostasis of the tooth-supporting system. Inhibits BMP2-induced cytodifferentiation of PDL cells by preventing its binding to BMPR1B/BMP type-1B receptor; resulting in inhibition of BMP-dependent activation of SMAD proteins (By similarity). Critical regulator of TGF-beta in articular cartilage and plays an essential role in cartilage homeostasis and osteoarthritis (OA) pathogenesis. Negatively regulates chondrogenesis in the articular cartilage by blocking the TGF-beta/receptor interaction on the cell surface and inhibiting the canonical TGF-beta/Smad signal. Binds calcium and plays a role in osteoblast-driven collagen biomineralization activity.
- Gene Details:
- asporin
- Molecular Weight:
- 55.7 kDa
- Protein Details:
- Asporin
- Purity:
- Greater than 90% as determined by SDS-PAGE.
- Shipping Conditions:
- Blue Ice
- Source:
- E.coli
- Storage Conditions:
- -20Â[o]C or -80Â[o]C
- Supplier:
- Aviva Systems Biology
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Recombinant Proteins
- Manufacturer's Data Sheet:html_datasheet.php
