TRIM21 Recombinant Protein
Product Sizes
20ug
£398.00
OPCA04129-20UG
100ug
£550.00
OPCA04129-100UG
About this Product
- SKU:
- OPCA04129
- Additional Names:
- 52 kDa ribonucleoprotein autoantigen Ro/SS-A;52 kDa Ro protein;E3 ubiquitin-protein ligase TRIM21;RING finger protein 81;RING-type E3 ubiquitin transferase TRIM21;RNF81;ro(SS-A);Ro/SSA;Ro/SSA 52kDa;RO52;Sicca syndrome antigen A;sjoegren syndrome type A antigen;Sjogren syndrome antigen A1 (52kDa; ribonucleoprotein autoantigen SS-A/Ro);SSA;SS-A;SSA1;tripartite motif-containing protein 21.
- Concentration:
- Varies by lot. See vial for exact concentration.
- Extra Details:
- E3 ubiquitin-protein ligase whose activity is dependent on E2 enzymes; UBE2D1; UBE2D2; UBE2E1 and UBE2E2. Forms a ubiquitin ligase complex in cooperation with the E2 UBE2D2 that is used not only for the ubiquitination of USP4 and IKBKB but also for its self-ubiquitination. Component of cullin-RING-based SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complexes such as SCF(SKP2)-like complexes. A TRIM21-containing SCF(SKP2)-like complex is shown to mediate ubiquitination of CDKN1B ('Thr-187' phosphorylated-form); thereby promoting its degradation by the proteasome. Monoubiquitinates IKBKB that will negatively regulates Tax-induced NF-kappa-B signaling. Negatively regulates IFN-beta production post-pathogen recognition by polyubiquitin-mediated degradation of IRF3. Mediates the ubiquitin-mediated proteasomal degradation of IgG1 heavy chain; which is linked to the VCP-mediated ER-associated degradation (ERAD) pathway. Promotes IRF8 ubiquitination; which enhanced the ability of IRF8 to stimulate cytokine genes transcription in macrophages. Plays a role in the regulation of the cell cycle progression. Enhances the decapping activity of DCP2. Exists as a ribonucleoprotein particle present in all mammalian cells studied and composed of a single polypeptide and one of four small RNA molecules. At least two isoforms are present in nucleated and red blood cells; and tissue specific differences in RO/SSA proteins have been identified. The common feature of these proteins is their ability to bind HY RNAs.2. Involved in the regulation of innate immunity and the inflammatory response in response to IFNG/IFN-gamma. Organizes autophagic machinery by serving as a platform for the assembly of ULK1; Beclin 1/BECN1 and ATG8 family members and recognizes specific autophagy targets; thus coordinating target recognition with assembly of the autophagic apparatus and initiation of autophagy. Acts as an autophagy receptor for the degradation of IRF3; hence attenuating type I interferon (IFN)-dependent immune responses (PubMed:26347139).
- Gene Details:
- tripartite motif containing 21
- Molecular Weight:
- 56.2 kDa
- Protein Details:
- E3 ubiquitin-protein ligase TRIM21
- Purity:
- Greater than 90% as determined by SDS-PAGE.
- Purification:
- Affinity purified using IMAC
- Shipping Conditions:
- Blue Ice
- Source:
- Yeast
- Storage Conditions:
- Store at -20°C; for extended storage; conserve at -20°C or -80°C. Store working aliquots at 4°C for up to one week. Repeated freezing and thawing is not recommended.
- Supplier:
- Aviva Systems Biology
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Recombinant Proteins
- Manufacturer's Data Sheet:html_datasheet.php
