TNFRSF21 Recombinant Protein
Product Sizes
20ug
£348.00
OPCA03968-20UG
100ug
£500.00
OPCA03968-100UG
1mg
£1822.00
OPCA03968-1MG
About this Product
- SKU:
- OPCA03968
- Additional Names:
- BM-018;CD358;death receptor 6;DR6;TNFR-related death receptor 6;tumor necrosis factor receptor superfamily member 21.
- Extra Details:
- Promotes apoptosis; possibly via a pathway that involves the activation of NF-kappa-B. Can also promote apoptosis mediated by BAX and by the release of cytochrome c from the mitochondria into the cytoplasm. Plays a role in neuronal apoptosis; including apoptosis in response to amyloid peptides derived from APP; and is required for both normal cell body death and axonal pruning. Trophic-factor deprivation triggers the cleavage of surface APP by beta-secretase to release sAPP-beta which is further cleaved to release an N-terminal fragment of APP (N-APP). N-APP binds TNFRSF21; this triggers caspase activation and degeneration of both neuronal cell bodies (via caspase-3) and axons (via caspase-6). Negatively regulates oligodendrocyte survival; maturation and myelination. Plays a role in signaling cascades triggered by stimulation of T-cell receptors; in the adaptive immune response and in the regulation of T-cell differentiation and proliferation. Negatively regulates T-cell responses and the release of cytokines such as IL4; IL5; IL10; IL13 and IFNG by Th2 cells. Negatively regulates the production of IgG; IgM and IgM in response to antigens. May inhibit the activation of JNK in response to T-cell stimulation.
- Gene Details:
- TNF receptor superfamily member 21
- Molecular Weight:
- 48 kDa
- Protein Details:
- Tumor necrosis factor receptor superfamily member 21
- Purity:
- Greater than 90% as determined by SDS-PAGE.
- Shipping Conditions:
- Blue Ice
- Source:
- E.coli
- Storage Conditions:
- -20Â[o]C or -80Â[o]C
- Supplier:
- Aviva Systems Biology
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Recombinant Proteins
- Manufacturer's Data Sheet:html_datasheet.php
