P4HB Recombinant Protein
Product Sizes
20ug
£348.00
OPCA03914-20UG
100ug
£500.00
OPCA03914-100UG
1mg
£1822.00
OPCA03914-1MG
About this Product
- SKU:
- OPCA03914
- Additional Names:
- cellular thyroid hormone-binding protein;CLCRP1;collagen prolyl 4-hydroxylase beta;DSI;ERBA2L;GIT;glutathione-insulin transhydrogenase;P4Hbeta;p55;PDI;PDIA1;PHDB;PO4DB;PO4HB;procollagen-proline; 2-oxoglutarate 4-dioxygenase (proline 4-hydroxylase); beta polypeptide;PROHB;Prolyl 4-hydroxylase subunit beta;prolyl 4-hydroxylase; beta polypeptide;protein disulfide isomerase family A; member 1;protein disulfide isomerase/oxidoreductase;protein disulfide isomerase-associated 1;protein disulfide-isomerase;protocollagen hydroxylase;testicular secretory protein Li 32;thyroid hormone-binding protein p55.
- Extra Details:
- This multifunctional protein catalyzes the formation; breakage and rearrangement of disulfide bonds. At the cell surface; seems to act as a reductase that cleaves disulfide bonds of proteins attached to the cell. May therefore cause structural modifications of exofacial proteins. Inside the cell; seems to form/rearrange disulfide bonds of nascent proteins. At high concentrations; functions as a chaperone that inhibits aggregation of misfolded proteins. At low concentrations; facilitates aggregation (anti-chaperone activity). May be involved with other chaperones in the structural modification of the TG precursor in hormone biogenesis. Also acts a structural subunit of various enzymes such as prolyl 4-hydroxylase and microsomal triacylglycerol transfer protein MTTP. Receptor for LGALS9; the interaction retains P4HB at the cell surface of Th2 T helper cells; increasing disulfide reductase activity at the plasma membrane; altering the plasma membrane redox state and enhancing cell migration (PubMed:21670307).
- Gene Details:
- prolyl 4-hydroxylase subunit beta
- Molecular Weight:
- 59.3 kDa
- Protein Details:
- Protein disulfide-isomerase
- Purity:
- Greater than 90% as determined by SDS-PAGE.
- Shipping Conditions:
- Blue Ice
- Source:
- E.coli
- Storage Conditions:
- -20Â[o]C or -80Â[o]C
- Supplier:
- Aviva Systems Biology
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Recombinant Proteins
- Manufacturer's Data Sheet:html_datasheet.php
