DHX9 Recombinant Protein
Product Sizes
20ug
£615.00
OPCA03645-20UG
100ug
£1547.00
OPCA03645-100UG
About this Product
- SKU:
- OPCA03645
- Additional Names:
- ATP-dependent RNA helicase A;DDX9;DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 9;DEAH (Asp-Glu-Ala-His) box helicase 9;DEAH (Asp-Glu-Ala-His) box polypeptide 9;DEAH box protein 9;DEAH-box helicase 9;DExH-box helicase 9;leukophysin;LKP;NDH2;NDHII;nuclear DNA helicase II;RHA;RNA helicase A.
- Extra Details:
- Multifunctional ATP-dependent nucleic acid helicase that unwinds DNA and RNA in a 3' to 5' direction and that plays important roles in many processes; such as DNA replication; transcriptional activation; post-transcriptional RNA regulation; mRNA translation and RNA-mediated gene silencing (PubMed:9111062; PubMed:11416126; PubMed:12711669; PubMed:15355351; PubMed:16680162; PubMed:17531811; PubMed:20669935; PubMed:21561811; PubMed:24049074; PubMed:25062910; PubMed:24990949; PubMed:28221134). Requires a 3'-single-stranded tail as entry site for acid nuclei unwinding activities as well as the binding and hydrolyzing of any of the four ribo- or deoxyribo-nucleotide triphosphates (NTPs) (PubMed:1537828). Unwinds numerous nucleic acid substrates such as double-stranded (ds) DNA and RNA; DNA:RNA hybrids; DNA and RNA forks composed of either partially complementary DNA duplexes or DNA:RNA hybrids; respectively; and also DNA and RNA displacement loops (D- and R-loops); triplex-helical DNA (H-DNA) structure and DNA and RNA-based G-quadruplexes (PubMed:20669935; PubMed:21561811; PubMed:24049074). Binds dsDNA; single-stranded DNA (ssDNA); dsRNA; ssRNA and poly(A)-containing RNA (PubMed:9111062; PubMed:10198287). Binds also to circular dsDNA or dsRNA of either linear and/or circular forms and stimulates the relaxation of supercoiled DNAs catalyzed by topoisomerase TOP2A (PubMed:12711669). Plays a role in DNA replication at origins of replication and cell cycle progression (PubMed:24990949). Plays a role as a transcriptional coactivator acting as a bridging factor between polymerase II holoenzyme and transcription factors or cofactors; such as BRCA1; CREBBP; RELA and SMN1 (PubMed:11149922; PubMed:9323138; PubMed:9662397; PubMed:11038348; PubMed:11416126; PubMed:15355351; PubMed:28221134). Binds to the CDKN2A promoter (PubMed:11038348). Plays several roles in post-transcriptional regulation of gene expression (PubMed:28221134; PubMed:28355180). In cooperation with NUP98; promotes pre-mRNA alternative splicing activities of a subset of genes (PubMed:11402034; PubMed:16680162; PubMed:28221134; PubMed:28355180). As component of a large PER complex; is involved in the negative regulation of 3' transcriptional termination of circadian target genes such as PER1 and NR1D1 and the control of the circadian rhythms (By similarity). Acts also as a nuclear resolvase that is able to bind and neutralize harmful massive secondary double-stranded RNA structures formed by inverted-repeat Alu retrotransposon elements that are inserted and transcribed as parts of genes during the process of gene transposition (PubMed:28355180). Involved in the positive regulation of nuclear export of constitutive transport element (CTE)-containing unspliced mRNA (PubMed:9162007; PubMed:10924507; PubMed:11402034). Component of the coding region determinant (CRD)-mediated complex that promotes cytoplasmic MYC mRNA stability (PubMed:19029303). Plays a role in mRNA translation (PubMed:28355180). Positively regulates translation of selected mRNAs through its binding to post-transcriptional control element (PCE) in the 5'-untranslated region (UTR) (PubMed:16680162). Involved with LARP6 in the translation stimulation of type I collagen mRNAs for CO1A1 and CO1A2 through binding of a specific stem-loop structure in their 5'-UTRs (PubMed:22190748). Stimulates LIN28A-dependent mRNA translation probably by facilitating ribonucleoprotein remodeling during the process of translation (PubMed:21247876). Plays also a role as a small interfering (siRNA)-loading factor involved in the RNA-induced silencing complex (RISC) loading complex (RLC) assembly; and hence functions in the RISC-mediated gene silencing process (PubMed:17531811). Binds preferentially to short double-stranded RNA; such as those produced during rotavirus intestinal infection (PubMed:28636595). This interaction may mediate NLRP9 inflammasome activation and trigger inflammatory response; including IL18 release and pyroptosis (PubMed:28636595). Finally; mediates the attachment of heterogeneous nuclear ribonucleoproteins (hnRNPs) to actin filaments in the nucleus (PubMed:11687588).
- Gene Details:
- DExH-box helicase 9
- Host:
- Human
- Molecular Weight:
- 61.6 kDa
- Protein Details:
- ATP-dependent RNA helicase A
- Purity:
- Greater than 90% as determined by SDS-PAGE.
- Shipping Conditions:
- Blue Ice
- Source:
- Mammalian Cells
- Storage Conditions:
- -20Â[o]C or -80Â[o]C
- Supplier:
- Aviva Systems Biology
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Recombinant Proteins
- Manufacturer's Data Sheet:html_datasheet.php
