Ube3a Recombinant Protein
Product Sizes
20ug
£561.00
OPCA03595-20UG
100ug
£793.00
OPCA03595-100UG
1mg
£2446.00
OPCA03595-1MG
About this Product
- SKU:
- OPCA03595
- Additional Names:
- 4732496B02;5830462N02Rik;A130086L21Rik;E6-AP ubiquitin protein ligase;HECT-type ubiquitin transferase E3A;Hpv;Hpve6a;oncogenic protein-associated protein E6-AP;ubiquitin conjugating enzyme E3A;ubiquitin-protein ligase E3A.
- Extra Details:
- E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and transfers it to its substrates. Several substrates have been identified including the ARNTL/BMAL1; ARC; RAD23A and RAD23B; MCM7 (which is involved in DNA replication); annexin A1; the PML tumor suppressor; and the cell cycle regulator CDKN1B (PubMed:20211139; PubMed:24728990). Additionally; may function as a cellular quality control ubiquitin ligase by helping the degradation of the cytoplasmic misfolded proteins. Finally; UBE3A also promotes its own degradation in vivo (By similarity). Plays an important role in the regulation of the circadian clock: involved in the ubiquitination of the core clock component ARNTL/BMAL1; leading to its proteasomal degradation (PubMed:24728990). Acts as a regulator of synaptic development by mediating ubiquitination and degradation of ARC (PubMed:20211139). Synergizes with WBP2 in enhancing PGR activity (By similarity).
- Gene Details:
- ubiquitin protein ligase E3A
- Host:
- Mouse
- Molecular Weight:
- 41.9 kDa
- Protein Details:
- Ubiquitin-protein ligase E3A
- Purity:
- Greater than 90% as determined by SDS-PAGE.
- Shipping Conditions:
- Blue Ice
- Source:
- E.coli
- Storage Conditions:
- -20Â[o]C or -80Â[o]C
- Supplier:
- Aviva Systems Biology
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Recombinant Proteins
- Manufacturer's Data Sheet:html_datasheet.php
