lexA Recombinant Protein
Product Sizes
20ug
£561.00
OPCA03516-20UG
100ug
£793.00
OPCA03516-100UG
1mg
£2446.00
OPCA03516-1MG
About this Product
- SKU:
- OPCA03516
- Additional Names:
- b4043;DNA-binding transcriptional repressor LexA;ECK4035;exrA;spr;tsl;umuA.
- Extra Details:
- Represses a number of genes involved in the response to DNA damage (SOS response); including recA and lexA. Binds to the 16 bp palindromic sequence 5'-CTGTATATATATACAG-3'. In the presence of single-stranded DNA; RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA; leading to derepression of the SOS regulon and eventually DNA repair. Implicated in hydroxy radical-mediated cell death induced by hydroxyurea treatment (PubMed:20005847).The SOS response controls an apoptotic-like death (ALD) induced (in the absence of the mazE-mazF toxin-antitoxin module) in response to DNA damaging agents that is mediated by RecA and LexA (PubMed:22412352).
- Gene Details:
- DNA-binding transcriptional repressor LexA
- Molecular Weight:
- 38.4 kDa
- Protein Details:
- LexA repressor
- Purity:
- Greater than 90% as determined by SDS-PAGE.
- Shipping Conditions:
- Blue Ice
- Source:
- E.coli
- Storage Conditions:
- -20Â[o]C or -80Â[o]C
- Supplier:
- Aviva Systems Biology
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Recombinant Proteins
- Manufacturer's Data Sheet:html_datasheet.php
