PLD6 Recombinant Protein
Product Sizes
20ug
£463.00
OPCA03428-20UG
100ug
£652.00
OPCA03428-100UG
1mg
£2446.00
OPCA03428-1MG
About this Product
- SKU:
- OPCA03428
- Additional Names:
- choline phosphatase 6;mitochondrial cardiolipin hydrolase;mitochondrial phospholipase;mitoPLD;phosphatidylcholine-hydrolyzing phospholipase D6;phospholipase D6;PLD 6;protein zucchini homolog;ZUC.
- Extra Details:
- Endonuclease that plays a critical role in PIWI-interacting RNA (piRNA) biogenesis during spermatogenesis. piRNAs provide essential protection against the activity of mobile genetic elements (By similarity). piRNA-mediated transposon silencing is thus critical for maintaining genome stability; in particular in germline cells when transposons are mobilized as a consequence of wide-spread genomic demethylation (By similarity). Has been proposed to act as a cardiolipin hydrolase to generate phosphatidic acid at mitochondrial surface (By similarity). Although it cannot be excluded that it can act as a phospholipase in some circumstances; it should be noted that cardiolipin hydrolase activity is either undetectable in vitro; or very low (PubMed:21397848). In addition; cardiolipin is almost exclusively found on the inner mitochondrial membrane; while PLD6 localizes to the outer mitochondrial membrane; facing the cytosol (PubMed:21397848). Has been shown to be a backbone-non-specific; single strand-specific nuclease; cleaving either RNA or DNA substrates with similar affinity. Produces 5' phosphate and 3' hydroxyl termini; suggesting it could directly participate in the processing of primary piRNA transcripts (By similarity). Also acts as a regulator of mitochondrial shape through facilitating mitochondrial fusion (PubMed:17028579; PubMed:26711011).
- Gene Details:
- phospholipase D family member 6
- Host:
- Human
- Molecular Weight:
- 44.3 kDa
- Protein Details:
- Mitochondrial cardiolipin hydrolase
- Purity:
- Greater than 90% as determined by SDS-PAGE.
- Shipping Conditions:
- Blue Ice
- Source:
- E.coli
- Storage Conditions:
- -20Â[o]C or -80Â[o]C
- Supplier:
- Aviva Systems Biology
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Recombinant Proteins
- Manufacturer's Data Sheet:html_datasheet.php
