AaH2 Recombinant Protein
Product Sizes
20ug
£561.00
OPCA03379-20UG
100ug
£793.00
OPCA03379-100UG
1mg
£2446.00
OPCA03379-1MG
About this Product
- SKU:
- OPCA03379
- Additional Names:
- AaH II;Neurotoxin 2.
- Extra Details:
- Alpha toxins bind voltage-independently at site-3 of sodium channels (Nav) and inhibit the inactivation of the activated channels; thereby blocking neuronal transmission. The toxin principally slows the inactivation process of TTX-sensitive sodium channels (PubMed:23685008). It is active on rat brain Nav1.2/SCN2A sodium channel (EC(50)=2.6 nM) and on rat skeletal muscle Nav1.4/SCN4A sodium channel (EC(50)=2.2 nM) (PubMed:12911331); as well as on human neuronal Nav1.7/SCN9A (EC(50)=6.8 nM) (PubMed:23685008). This toxin is active against mammals. In vivo; intraplantar injection into mice induces spontaneous pain responses (PubMed:23685008).
- Molecular Weight:
- 23.3 kDa
- Protein Details:
- Alpha-mammal toxin AaH2
- Purity:
- Greater than 90% as determined by SDS-PAGE.
- Shipping Conditions:
- Blue Ice
- Source:
- E.coli
- Storage Conditions:
- -20Â[o]C or -80Â[o]C
- Supplier:
- Aviva Systems Biology
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Recombinant Proteins
- Manufacturer's Data Sheet:html_datasheet.php
