PNTx4 Recombinant Protein
Product Sizes
20ug
£615.00
OPCA03289-20UG
100ug
£886.00
OPCA03289-100UG
About this Product
- SKU:
- OPCA03289
- Additional Names:
- Insecticidal neurotoxin Tx4(6-1).
- Extra Details:
- This neurotoxin binds at site 3 of insect voltage-activated sodium channels (Nav) and prolongs evoked axonal action potentials by a slowing down of sodium current inactivation (PubMed:12770132). The toxin also inhibits glutamate uptake from rat brain synaptosomes (PubMed:14757211). It reversibly inhibits the N-methyl-D-aspartate (NMDA)-subtype of ionotropic glutamate receptor (GRIN) (By similarity). In addition; the toxin shows antinociceptive effect in all rat pain models tested (inflammatory; neuropathic and nociceptive) (PubMed:27077886). The antinociceptive effect is partially blocked when selective antagonists of both mu- and delta-opioid receptors are administered; revealing that the antinociceptive effect of the toxin involves both opiod and cannabinoid endogenous systems (PubMed:27077886). In vivo; it is highly toxic to house fly (Musca domestica); toxic to cockroach; but has no effect when intracerebroventricularly injected into mice (PubMed:7778132; PubMed:12770132).
- Molecular Weight:
- 7.3 kDa
- Protein Details:
- Delta-ctenitoxin-Pn1a
- Purity:
- Greater than 90% as determined by SDS-PAGE.
- Shipping Conditions:
- Blue Ice
- Source:
- Yeast
- Storage Conditions:
- -20Â[o]C or -80Â[o]C
- Supplier:
- Aviva Systems Biology
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Recombinant Proteins
- Manufacturer's Data Sheet:html_datasheet.php
