Arid5a Recombinant Protein
Product Sizes
20ug
£532.00
OPCA03247-20UG
100ug
£760.00
OPCA03247-100UG
About this Product
- SKU:
- OPCA03247
- Additional Names:
- ARID domain-containing protein 5A;AT rich interactive domain 5A (Mrf1 like);AT-rich interactive domain-containing protein 5A;D430024K22Rik;modulator recognition factor I;Mrf;Mrf1.
- Extra Details:
- DNA-binding protein that may regulate transcription and act as a repressor by binding to AT-rich stretches in the promoter region of target genes (By similarity). May positively regulate chondrocyte-specific transcription such as of COL2A1 in collaboration with SOX9 and positively regulate histone H3 acetylation at chondrocyte-specific genes. May stimulate early-stage chondrocyte differentiation and inhibit later stage differention (PubMed:21346191). Can repress ESR1-mediated transcriptional activation; proposed to act as corepressor for selective nuclear hormone receptors (By similarity). As RNA-binding protein involved in the regulation of inflammatory response by stabilizing selective inflammation-related mRNAs; such as IL6; STAT3 and TBX21. Binds to stem loop structures located in the 3'UTRs of IL6; STAT3 and TBX21 mRNAs; at least for STAT3 prevents binding of ZC3H12A to the mRNA stem loop structure thus inhibiting its degradation activity. Contributes to elevated IL6 levels possibly implicated in autoimmunity processes. IL6-dependent stabilization of STAT3 mRNA may promote differentiation of naive CD4+ T-cells into T-helper Th17 cells (PubMed:23676272; PubMed:27022145). In CD4+ T-cells may also inhibit RORC-induced Th17 cell differentiation independently of IL6 signaling (PubMed:24782182). Stabilization of TBX21 mRNA contributes to elevated interferon-gamma secretion in Th1 cells possibly implicated in the establishment of septic shock (PubMed:27671645).
- Gene Details:
- AT rich interactive domain 5A (MRF1-like)
- Host:
- Mouse
- Molecular Weight:
- 65.9 kDa
- Protein Details:
- AT-rich interactive domain-containing protein 5A
- Purity:
- Greater than 90% as determined by SDS-PAGE.
- Purification:
- Affinity purified using IMAC.
- Shipping Conditions:
- Blue Ice
- Source:
- Yeast
- Storage Conditions:
- -20Â[o]C or -80Â[o]C
- Supplier:
- Aviva Systems Biology
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Recombinant Proteins
- Manufacturer's Data Sheet:html_datasheet.php
