C1orf106 Recombinant Protein
Product Sizes
20ug
£398.00
OPCA03019-20UG
100ug
£550.00
OPCA03019-100UG
About this Product
- SKU:
- OPCA03019
- Additional Names:
- C1orf106;innate immunity activator protein;uncharacterized protein C1orf106.
- Extra Details:
- Expressed in peripheral macrophages and intestinal myeloid-derived cells; is required for optimal PRR (pattern recognition receptor)-induced signaling; cytokine secretion; and bacterial clearance. Upon stimulation of a broad range of PRRs (pattern recognition receptor) such as NOD2 or TLR2; TLR3; TLR4; TLR5; TLR7 and TLR9; associates with YWHAQ/14-3-3T; which in turn leads to the recruitment and activation of MAP kinases and NF-kappa-B signaling complexes that amplifies PRR-induced downstream signals and cytokine secretion (PubMed:28436939). In the intestine; regulates adherens junction stability by regulating the degradation of CYTH1 and CYTH2; probably acting as substrate cofactor for SCF E3 ubiquitin-protein ligase complexes. Stabilizes adherens junctions by limiting CYTH1-dependent ARF6 activation (PubMed:29420262).
- Gene Details:
- innate immunity activator
- Host:
- Human
- Molecular Weight:
- 65.5 kDa
- Protein Details:
- Innate immunity activator protein
- Purity:
- Greater than 90% as determined by SDS-PAGE.
- Shipping Conditions:
- Blue Ice
- Source:
- Yeast
- Storage Conditions:
- -20Â[o]C or -80Â[o]C
- Supplier:
- Aviva Systems Biology
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Recombinant Proteins
- Manufacturer's Data Sheet:html_datasheet.php
