SMARCA2 Recombinant Protein
Product Sizes
20ug
£398.00
OPCA02797-20UG
100ug
£550.00
OPCA02797-100UG
About this Product
- SKU:
- OPCA02797
- Additional Names:
- ATP-dependent helicase SMARCA2;BAF190;BAF190B;BIS;brahma homolog;BRG1-associated factor 190B;BRM;global transcription activator homologous sequence;hBRM;hSNF2a;NCBRS;probable global transcription activator SNF2L2;protein brahma homolog;SNF2;SNF2/SWI2-like protein 2;SNF2-alpha;SNF2L2;SNF2LA;Sth1p;sucrose nonfermenting 2-like protein 2;SWI/SNF-related matrix-associated actin-dependent regulator of chromatin a2;SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 2;SWI2.
- Concentration:
- Varies by lot. See vial for concentration.
- Extra Details:
- Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Component of SWI/SNF chromatin remodeling complexes that carry out key enzymatic activities; changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner. Binds DNA non-specifically (PubMed:22952240; PubMed:26601204). Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a postmitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to postmitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons; npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A; are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth (By similarity).
- Gene Details:
- SWI/SNF related; matrix associated; actin dependent regulator of chromatin; subfamily a; member 2
- Host:
- Human
- Molecular Weight:
- 61.7 kDa
- Protein Details:
- Probable global transcription activator SNF2L2
- Purity:
- Greater than 90% as determined by SDS-PAGE.
- Purification:
- Affinity purified using IMAC
- Shipping Conditions:
- Blue Ice
- Source:
- Yeast
- Storage Conditions:
- -20Â[o]C or -80Â[o]C
- Supplier:
- Aviva Systems Biology
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Recombinant Proteins
- Manufacturer's Data Sheet:html_datasheet.php
