FZR1 Recombinant Protein
Product Sizes
20ug
£348.00
OPCA02549-20UG
100ug
£500.00
OPCA02549-100UG
1mg
£1822.00
OPCA02549-1MG
About this Product
- SKU:
- OPCA02549
- Additional Names:
- CDC20 homolog 1;CDC20C;CDC20-like 1b;CDC20-like protein 1;CDH1;cdh1/Hct1 homolog;fizzy/cell division cycle 20 related 1;fizzy-related protein homolog;FZR;FZR2;HCDH;HCDH1.
- Concentration:
- Varies by lot. See vial for concentration.
- Extra Details:
- Substrate-specific adapter for the anaphase promoting complex/cyclosome (APC/C) E3 ubiquitin-protein ligase complex. Associates with the APC/C in late mitosis; in replacement of CDC20; and activates the APC/C during anaphase and telophase. The APC/C remains active in degrading substrates to ensure that positive regulators of the cell cycle do not accumulate prematurely. At the G1/S transition FZR1 is phosphorylated; leading to its dissociation from the APC/C. Following DNA damage; it is required for the G2 DNA damage checkpoint: its dephosphorylation and reassociation with the APC/C leads to the ubiquitination of PLK1; preventing entry into mitosis. Acts as an adapter for APC/C to target the DNA-end resection factor RBBP8/CtIP for ubiquitination and subsequent proteasomal degradation. Through the regulation of RBBP8/CtIP protein turnover; may play a role in DNA damage response; favoring DNA double-strand repair through error-prone non-homologous end joining (NHEJ) over error-free; RBBP8-mediated homologous recombination (HR) (PubMed:25349192).
- Gene Details:
- fizzy and cell division cycle 20 related 1
- Host:
- Human
- Molecular Weight:
- 70.8 kDa
- Protein Details:
- Fizzy-related protein homolog
- Purity:
- Greater than 90% as determined by SDS-PAGE.
- Purification:
- Affinity purified using IMAC
- Shipping Conditions:
- Blue Ice
- Source:
- E.coli
- Storage Conditions:
- -20Â[o]C or -80Â[o]C
- Supplier:
- Aviva Systems Biology
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Recombinant Proteins
- Manufacturer's Data Sheet:html_datasheet.php
