MOB1A Recombinant Protein
Product Sizes
20ug
£348.00
OPCA02488-20UG
100ug
£500.00
OPCA02488-100UG
1mg
£1822.00
OPCA02488-1MG
About this Product
- SKU:
- OPCA02488
- Additional Names:
- C2orf6;MABKL1B;MATS1;MOB kinase activator 1A;MOB1;mob1 alpha;mob1 homolog 1B;MOB1 Mps One Binder homolog A;MOB1; Mps One Binder kinase activator-like 1B;Mob4B;MOBK1B;MOBKL1B;mps one binder kinase activator-like 1B.
- Extra Details:
- Activator of LATS1/2 in the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1; in complex with its regulatory protein SAV1; phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1; which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS1/2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation; cell death; and cell migration. Stimulates the kinase activity of STK38 and STK38L. Acts cooperatively with STK3/MST2 to activate STK38.
- Gene Details:
- MOB kinase activator 1A
- Host:
- Human
- Molecular Weight:
- 40.9 kDa
- Protein Details:
- MOB kinase activator 1A
- Purity:
- Greater than 90% as determined by SDS-PAGE.
- Shipping Conditions:
- Blue Ice
- Source:
- E.coli
- Storage Conditions:
- -20Â[o]C or -80Â[o]C
- Supplier:
- Aviva Systems Biology
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Recombinant Proteins
- Manufacturer's Data Sheet:html_datasheet.php
