NEIL1 Recombinant Protein
Product Sizes
20ug
£348.00
OPCA02411-20UG
100ug
£500.00
OPCA02411-100UG
1mg
£1822.00
OPCA02411-1MG
About this Product
- SKU:
- OPCA02411
- Additional Names:
- DNA endonuclease eight-like glycosylase 1;DNA glycosylase/AP lyase Neil1;DNA-(apurinic or apyrimidinic site) lyase Neil1;endonuclease 8-like 1;endonuclease VIII;endonuclease VIII-like 1;FPG1;hFPG1;NEH1;nei endonuclease VIII-like 1;nei homolog 1;NEI1;nei-like protein 1.
- Extra Details:
- Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized pyrimidines; such as thymine glycol; formamidopyrimidine (Fapy) and 5-hydroxyuracil. Has marginal activity towards 8-oxoguanine. Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates. Has DNA glycosylase/lyase activity towards mismatched uracil and thymine; in particular in U:C and T:C mismatches. Specifically binds 5-hydroxymethylcytosine (5hmC); suggesting that it acts as a specific reader of 5hmC.
- Gene Details:
- nei like DNA glycosylase 1
- Host:
- Human
- Molecular Weight:
- 59.6 kDa
- Protein Details:
- Endonuclease 8-like 1
- Purity:
- Greater than 90% as determined by SDS-PAGE.
- Shipping Conditions:
- Blue Ice
- Source:
- E.coli
- Storage Conditions:
- -20Â[o]C or -80Â[o]C
- Supplier:
- Aviva Systems Biology
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Recombinant Proteins
- Manufacturer's Data Sheet:html_datasheet.php
