TRAF6 Recombinant Protein
Product Sizes
20ug
£348.00
OPCA01912-20UG
100ug
£500.00
OPCA01912-100UG
1mg
£1822.00
OPCA01912-1MG
About this Product
- SKU:
- OPCA01912
- Additional Names:
- E3 ubiquitin-protein ligase TRAF6;interleukin-1 signal transducer;MGC:3310;RING finger protein 85;RING-type E3 ubiquitin transferase TRAF6;RNF85;TNF receptor-associated factor 6;TNF receptor-associated factor 6; E3 ubiquitin protein ligase.
- Concentration:
- 0.1-5 mg/ml (Bradford method)
- Extra Details:
- E3 ubiquitin ligase that; together with UBE2N and UBE2V1; mediates the synthesis of 'Lys-63'-linked-polyubiquitin chains conjugated to proteins; such as IKBKG; IRAK1; AKT1 and AKT2. Also mediates ubiquitination of free/unanchored polyubiquitin chain that leads to MAP3K7 activation. Leads to the activation of NF-kappa-B and JUN. May be essential for the formation of functional osteoclasts. Seems to also play a role in dendritic cells (DCs) maturation and/or activation. Represses c-Myb-mediated transactivation; in B-lymphocytes. Adapter protein that seems to play a role in signal transduction initiated via TNF receptor; IL-1 receptor and IL-17 receptor. Regulates osteoclast differentiation by mediating the activation of adapter protein complex 1 (AP-1) and NF-kappa-B; in response to RANK-L stimulation. Together with MAP3K8; mediates CD40 signals that activate ERK in B-cells and macrophages; and thus may play a role in the regulation of immunoglobulin production.
- Gene Details:
- TNF receptor associated factor 6
- Host:
- Human
- Molecular Weight:
- 75.6 kDa
- Protein Details:
- TNF receptor-associated factor 6
- Purity:
- Greater than 90% as determined by SDS-PAGE.
- Purification:
- Affinity purified using IMAC.
- Shipping Conditions:
- Blue Ice
- Source:
- E.coli
- Storage Conditions:
- -20Â[o]C or -80Â[o]C
- Supplier:
- Aviva Systems Biology
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Recombinant Proteins
- Manufacturer's Data Sheet:html_datasheet.php
