STAT3 Recombinant Protein
Product Sizes
20ug
£348.00
OPCA01873-20UG
100ug
£500.00
OPCA01873-100UG
1mg
£1822.00
OPCA01873-1MG
About this Product
- SKU:
- OPCA01873
- Additional Names:
- acute-phase response factor;ADMIO;ADMIO1;APRF;DNA-binding protein APRF;HIES;signal transducer and activator of transcription 3.
- Extra Details:
- Signal transducer and transcription activator that mediates cellular responses to interleukins; KITLG/SCF; LEP and other growth factors (PubMed:10688651; PubMed:12359225; PubMed:12873986; PubMed:15194700; PubMed:17344214; PubMed:18242580; PubMed:23084476). Once activated; recruits coactivators; such as NCOA1 or MED1; to the promoter region of the target gene (PubMed:17344214). May mediate cellular responses to activated FGFR1; FGFR2; FGFR3 and FGFR4 (PubMed:12873986). Binds to the interleukin-6 (IL-6)-responsive elements identified in the promoters of various acute-phase protein genes (PubMed:12359225). Activated by IL31 through IL31RA (PubMed:15194700). Acts as a regulator of inflammatory response by regulating differentiation of naive CD4(+) T-cells into T-helper Th17 or regulatory T-cells (Treg): deacetylation and oxidation of lysine residues by LOXL3; leads to disrupt STAT3 dimerization and inhibit its transcription activity (PubMed:28065600). Involved in cell cycle regulation by inducing the expression of key genes for the progression from G1 to S phase; such as CCND1 (PubMed:17344214). Mediates the effects of LEP on melanocortin production; body energy homeostasis and lactation (By similarity). May play an apoptotic role by transctivating BIRC5 expression under LEP activation (PubMed:18242580). Cytoplasmic STAT3 represses macroautophagy by inhibiting EIF2AK2/PKR activity (PubMed:23084476). Plays a crucial role in basal beta cell functions; such as regulation of insulin secretion (By similarity).
- Gene Details:
- signal transducer and activator of transcription 3
- Host:
- Human
- Molecular Weight:
- 38.3 kDa
- Protein Details:
- Signal transducer and activator of transcription 3
- Purity:
- Greater than 90% as determined by SDS-PAGE.
- Purification:
- Affinity purified using IMAC
- Shipping Conditions:
- Blue Ice
- Source:
- E.coli
- Storage Conditions:
- -20Â[o]C or -80Â[o]C
- Supplier:
- Aviva Systems Biology
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Recombinant Proteins
- Manufacturer's Data Sheet:html_datasheet.php
