MSH6 Recombinant Protein
Product Sizes
20ug
£348.00
OPCA01736-20UG
100ug
£500.00
OPCA01736-100UG
1mg
£1822.00
OPCA01736-1MG
About this Product
- SKU:
- OPCA01736
- Additional Names:
- DNA mismatch repair protein Msh6;G/T mismatch-binding protein;GTBP;GTMBP;HNPCC5;HSAP;MMRCS3;mutS protein homolog 6;mutS-alpha 160 kDa subunit;p160;sperm-associated protein.
- Extra Details:
- Component of the post-replicative DNA mismatch repair system (MMR). Heterodimerizes with MSH2 to form MutS alpha; which binds to DNA mismatches thereby initiating DNA repair. When bound; MutS alpha bends the DNA helix and shields approximately 20 base pairs; and recognizes single base mismatches and dinucleotide insertion-deletion loops (IDL) in the DNA. After mismatch binding; forms a ternary complex with the MutL alpha heterodimer; which is thought to be responsible for directing the downstream MMR events; including strand discrimination; excision; and resynthesis. ATP binding and hydrolysis play a pivotal role in mismatch repair functions. The ATPase activity associated with MutS alpha regulates binding similar to a molecular switch: mismatched DNA provokes ADP-->ATP exchange; resulting in a discernible conformational transition that converts MutS alpha into a sliding clamp capable of hydrolysis-independent diffusion along the DNA backbone. This transition is crucial for mismatch repair. MutS alpha may also play a role in DNA homologous recombination repair. Recruited on chromatin in G1 and early S phase via its PWWP domain that specifically binds trimethylated 'Lys-36' of histone H3 (H3K36me3): early recruitment to chromatin to be replicated allowing a quick identification of mismatch repair to initiate the DNA mismatch repair reaction.
- Gene Details:
- mutS homolog 6
- Host:
- Human
- Molecular Weight:
- 60.1 kDa
- Protein Details:
- DNA mismatch repair protein Msh6
- Purity:
- Greater than 90% as determined by SDS-PAGE.
- Shipping Conditions:
- Blue Ice
- Source:
- E.coli
- Storage Conditions:
- -20Â[o]C or -80Â[o]C
- Supplier:
- Aviva Systems Biology
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Recombinant Proteins
- Manufacturer's Data Sheet:html_datasheet.php
