BRCC3 Recombinant Protein
Product Sizes
20ug
£348.00
OPCA01487-20UG
100ug
£500.00
OPCA01487-100UG
1mg
£1822.00
OPCA01487-1MG
About this Product
- SKU:
- OPCA01487
- Additional Names:
- BRCA1/BRCA2-containing complex subunit 3;BRCA1/BRCA2-containing complex subunit 36;BRCA1-A complex subunit BRCC36;BRCC36;BRISC complex subunit BRCC36;C6.1A;CXorf53;lys-63-specific deubiquitinase BRCC36.
- Extra Details:
- Metalloprotease that specifically cleaves 'Lys-63'-linked polyubiquitin chains (PubMed:19214193; PubMed:20656690; PubMed:24075985; PubMed:26344097). Does not have activity toward 'Lys-48'-linked polyubiquitin chains. Component of the BRCA1-A complex; a complex that specifically recognizes 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites; leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). In the BRCA1-A complex; it specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX; antagonizing the RNF8-dependent ubiquitination at double-strand breaks (DSBs) (PubMed:20656690). Catalytic subunit of the BRISC complex; a multiprotein complex that specifically cleaves 'Lys-63'-linked ubiquitin in various substrates (PubMed:20656690; PubMed:24075985; PubMed:26344097; PubMed:26195665). Mediates the specific 'Lys-63'-specific deubiquitination associated with the COP9 signalosome complex (CSN); via the interaction of the BRISC complex with the CSN complex (PubMed:19214193). The BRISC complex is required for normal mitotic spindle assembly and microtubule attachment to kinetochores via its role in deubiquitinating NUMA1 (PubMed:26195665). Plays a role in interferon signaling via its role in the deubiquitination of the interferon receptor IFNAR1; deubiquitination increases IFNAR1 activity by enhancing its stability and cell surface expression (PubMed:24075985; PubMed:26344097). Down-regulates the response to bacterial lipopolysaccharide (LPS) via its role in IFNAR1 deubiquitination (PubMed:24075985).
- Gene Details:
- BRCA1/BRCA2-containing complex subunit 3
- Host:
- Human
- Molecular Weight:
- 51.9 kDa
- Protein Details:
- Lys-63-specific deubiquitinase BRCC36
- Purity:
- Greater than 90% as determined by SDS-PAGE.
- Shipping Conditions:
- Blue Ice
- Source:
- E.coli
- Storage Conditions:
- -20Â[o]C or -80Â[o]C
- Supplier:
- Aviva Systems Biology
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Recombinant Proteins
- Manufacturer's Data Sheet:html_datasheet.php
