ATF2 Recombinant Protein
Product Sizes
20ug
£348.00
OPCA01473-20UG
100ug
£571.00
OPCA01473-100UG
1mg
£2132.00
OPCA01473-1MG
About this Product
- SKU:
- OPCA01473
- Additional Names:
- Activating transcription factor 2;activating transcription factor 2 splice variant ATF2-var2;cAMP response element-binding protein CRE-BP1;cAMP responsive element binding protein 2; formerly;cAMP-dependent transcription factor ATF-2;CREB2;CREB-2;CRE-BP1;cyclic AMP-dependent transcription factor ATF-2;cyclic AMP-responsive element-binding protein 2;HB16;histone acetyltransferase ATF2;TREB7.
- Extra Details:
- Transcriptional activator which regulates the transcription of various genes; including those involved in anti-apoptosis; cell growth; and DNA damage response. Dependent on its binding partner; binds to CRE (cAMP response element) consensus sequences (5'-TGACGTCA-3') or to AP-1 (activator protein 1) consensus sequences (5'-TGACTCA-3'). In the nucleus; contributes to global transcription and the DNA damage response; in addition to specific transcriptional activities that are related to cell development; proliferation and death. In the cytoplasm; interacts with and perturbs HK1- and VDAC1-containing complexes at the mitochondrial outer membrane; thereby impairing mitochondrial membrane potential; inducing mitochondrial leakage and promoting cell death. The phosphorylated form (mediated by ATM) plays a role in the DNA damage response and is involved in the ionizing radiation (IR)-induced S phase checkpoint control and in the recruitment of the MRN complex into the IR-induced foci (IRIF). Exhibits histone acetyltransferase (HAT) activity which specifically acetylates histones H2B and H4 in vitro. In concert with CUL3 and RBX1; promotes the degradation of KAT5 thereby attenuating its ability to acetylate and activate ATM. Can elicit oncogenic or tumor suppressor activities depending on the tissue or cell type.
- Gene Details:
- activating transcription factor 2
- Host:
- Human
- Molecular Weight:
- 70.5 kDa
- Protein Details:
- Cyclic AMP-dependent transcription factor ATF-2
- Purity:
- Greater than 90% as determined by SDS-PAGE.
- Shipping Conditions:
- Blue Ice
- Source:
- E.coli
- Storage Conditions:
- -20Â[o]C or -80Â[o]C
- Supplier:
- Aviva Systems Biology
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Recombinant Proteins
- Manufacturer's Data Sheet:html_datasheet.php
