Recombinant human HLA class II histocompatibility antigen; DP alpha 1 chain protein
Product Sizes
20ug
£348.00
OPCA01049-20UG
100ug
£500.00
OPCA01049-100UG
1mg
£1822.00
OPCA01049-1MG
About this Product
- SKU:
- OPCA01049
- Additional Names:
- DP(W3);DP(W4);DPA1;HLA class II histocompatibility antigen; DP alpha 1 chain;HLA DPA1;HLADP;HLA-DP1A;HLA-DPA;HLA-DPA1*01:03:01:New;HLA-DPA1*02:01:01:NEW;HLA-DPB1;HLASB;HLA-SB alpha chain;MHC class II antigen DP alpha chain;MHC class II DP alpha chain;MHC class II DP3-alpha;MHC class II DPA1;MHC class II HLA-DPA1 antigen;MHC class II protein;PLT1.
- Extra Details:
- Binds peptides derived from antigens that access the endocytic route of antigen presenting cells (APC) and presents them on the cell surface for recognition by the CD4 T-cells. The peptide binding cleft accommodates peptides of 10-30 residues. The peptides presented by MHC class II molecules are generated mostly by degradation of proteins that access the endocytic route; where they are processed by lysosomal proteases and other hydrolases. Exogenous antigens that have been endocytosed by the APC are thus readily available for presentation via MHC II molecules; and for this reason this antigen presentation pathway is usually referred to as exogenous. As membrane proteins on their way to degradation in lysosomes as part of their normal turn-over are also contained in the endosomal/lysosomal compartments; exogenous antigens must compete with those derived from endogenous components. Autophagy is also a source of endogenous peptides; autophagosomes constitutively fuse with MHC class II loading compartments. In addition to APCs; other cells of the gastrointestinal tract; such as epithelial cells; express MHC class II molecules and CD74 and act as APCs; which is an unusual trait of the GI tract. To produce a MHC class II molecule that presents an antigen; three MHC class II molecules (heterodimers of an alpha and a beta chain) associate with a CD74 trimer in the ER to form a heterononamer. Soon after the entry of this complex into the endosomal/lysosomal system where antigen processing occurs; CD74 undergoes a sequential degradation by various proteases; including CTSS and CTSL; leaving a small fragment termed CLIP (class-II-associated invariant chain peptide). The removal of CLIP is facilitated by HLA-DM via direct binding to the alpha-beta-CLIP complex so that CLIP is released. HLA-DM stabilizes MHC class II molecules until primary high affinity antigenic peptides are bound. The MHC II molecule bound to a peptide is then transported to the cell membrane surface. In B-cells; the interaction between HLA-DM and MHC class II molecules is regulated by HLA-DO. Primary dendritic cells (DCs) also to express HLA-DO. Lysosomal microenvironment has been implicated in the regulation of antigen loading into MHC II molecules; increased acidification produces increased proteolysis and efficient peptide loading.
- Gene Details:
- major histocompatibility complex; class II; DP alpha 1
- Molecular Weight:
- 26.3 kDa
- Protein Details:
- HLA class II histocompatibility antigen; DP alpha 1 chain
- Purity:
- Greater than 90% as determined by SDS-PAGE.
- Shipping Conditions:
- Blue Ice
- Source:
- E.coli
- Storage Conditions:
- -20Â[o]C or -80Â[o]C
- Supplier:
- Aviva Systems Biology
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Recombinant Proteins
- Manufacturer's Data Sheet:html_datasheet.php
