Recombinant human Ubiquitin-conjugating enzyme E2 K
Product Sizes
20ug
£348.00
OPCA00828-20UG
100ug
£500.00
OPCA00828-100UG
1mg
£1822.00
OPCA00828-1MG
About this Product
- SKU:
- OPCA00828
- Additional Names:
- E2 ubiquitin-conjugating enzyme K;E2(25K);E2-25K;HIP2;HIP-2;huntingtin-interacting protein 2;HYPG;LIG;UBC1;ubiquitin carrier protein;ubiquitin conjugating enzyme E2K;ubiquitin-conjugating enzyme E2 K;ubiquitin-conjugating enzyme E2(25K);ubiquitin-conjugating enzyme E2-25 KDA;ubiquitin-conjugating enzyme E2K (UBC1 homolog; yeast);ubiquitin-protein ligase.
- Extra Details:
- Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro; in the presence or in the absence of BRCA1-BARD1 E3 ubiquitin-protein ligase complex; catalyzes the synthesis of 'Lys-48'-linked polyubiquitin chains. Does not transfer ubiquitin directly to but elongates monoubiquitinated substrate protein. Mediates the selective degradation of short-lived and abnormal proteins; such as the endoplasmic reticulum-associated degradation (ERAD) of misfolded lumenal proteins. Ubiquitinates huntingtin. May mediate foam cell formation by the suppression of apoptosis of lipid-bearing macrophages through ubiquitination and subsequence degradation of p53/TP53. Proposed to be involved in ubiquitination and proteolytic processing of NF-kappa-B; in vitro supports ubiquitination of NFKB1. In case of infection by cytomegaloviruses may be involved in the US11-dependent degradation of MHC class I heavy chains following their export from the ER to the cytosol. In case of viral infections may be involved in the HPV E7 protein-dependent degradation of RB1.
- Gene Details:
- ubiquitin conjugating enzyme E2 K
- Molecular Weight:
- 26.3 kDa
- Protein Details:
- Ubiquitin-conjugating enzyme E2 K
- Purity:
- Greater than 90% as determined by SDS-PAGE.
- Shipping Conditions:
- Blue Ice
- Source:
- E.coli
- Storage Conditions:
- -20Â[o]C or -80Â[o]C
- Supplier:
- Aviva Systems Biology
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Enzymes
- Manufacturer's Data Sheet:html_datasheet.php
