CLU Recombinant Protein
Product Sizes
100ug
£554.00
OPCA00621-100UG
1mg
£2071.00
OPCA00621-1MG
About this Product
- SKU:
- OPCA00621
- Additional Names:
- AAG4;Aging-associated gene 4 protein;aging-associated protein 4;APOJ;APO-J;apolipoprotein J;CLI;CLU1;CLU2;clusterin;complement cytolysis inhibitor;complement lysis inhibitor;complement-associated protein SP-40;40;epididymis secretory sperm binding protein;ku70-binding protein 1;KUB1;NA1/NA2;SGP2;SGP-2;SP-40;sulfated glycoprotein 2;testosterone-repressed prostate message 2;TRPM2;TRPM-2.
- Extra Details:
- Isoform 1 functions as extracellular chaperone that prevents aggregation of nonnative proteins. Prevents stress-induced aggregation of blood plasma proteins. Inhibits formation of amyloid fibrils by APP; APOC2; B2M; CALCA; CSN3; SNCA and aggregation-prone LYZ variants (in vitro). Does not require ATP. Maintains partially unfolded proteins in a state appropriate for subsequent refolding by other chaperones; such as HSPA8/HSC70. Does not refold proteins by itself. Binding to cell surface receptors triggers internalization of the chaperone-client complex and subsequent lysosomal or proteasomal degradation. Secreted isoform 1 protects cells against apoptosis and against cytolysis by complement. Intracellular isoforms interact with ubiquitin and SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complexes and promote the ubiquitination and subsequent proteasomal degradation of target proteins. Promotes proteasomal degradation of COMMD1 and IKBKB. Modulates NF-kappa-B transcriptional activity. Nuclear isoforms promote apoptosis. Mitochondrial isoforms suppress BAX-dependent release of cytochrome c into the cytoplasm and inhibit apoptosis. Plays a role in the regulation of cell proliferation.
- Gene Details:
- clusterin
- Molecular Weight:
- 27.8 kDa
- Protein Details:
- Clusterin
- Purity:
- Greater than 90% as determined by SDS-PAGE.
- Shipping Conditions:
- Blue Ice
- Source:
- E.coli
- Storage Conditions:
- -20Â[o]C or -80Â[o]C
- Supplier:
- Aviva Systems Biology
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Recombinant Proteins
- Manufacturer's Data Sheet:html_datasheet.php
