ALG2 Recombinant Protein
Product Sizes
100ug
£500.00
OPCA00557-100UG
1mg
£1822.00
OPCA00557-1MG
About this Product
- SKU:
- OPCA00557
- Additional Names:
- ALG2;ALG-2;apoptosis-linked gene 2 protein homolog;PEF1B;probable calcium-binding protein ALG-2;programmed cell death protein 6.
- Extra Details:
- Calcium sensor that plays a key role in processes such as endoplasmic reticulum (ER)-Golgi vesicular transport; endosomal biogenesis or membrane repair. Acts as an adapter that bridges unrelated proteins or stabilizes weak protein-protein complexes in response to calcium: calcium-binding triggers exposure of apolar surface; promoting interaction with different sets of proteins thanks to 3 different hydrophobic pockets; leading to translocation to membranes (PubMed:20691033; PubMed:25667979). Involved in ER-Golgi transport by promoting the association between PDCD6IP and TSG101; thereby bridging together the ESCRT-III and ESCRT-I complexes (PubMed:19520058). Together with PEF1; acts as calcium-dependent adapter for the BCR(KLHL12) complex; a complex involved in ER-Golgi transport by regulating the size of COPII coats (PubMed:27716508). In response to cytosolic calcium increase; the heterodimer formed with PEF1 interacts with; and bridges together the BCR(KLHL12) complex and SEC31 (SEC31A or SEC31B); promoting monoubiquitination of SEC31 and subsequent collagen export; which is required for neural crest specification (PubMed:27716508). Involved in the regulation of the distribution and function of MCOLN1 in the endosomal pathway (PubMed:19864416). Promotes localization and polymerization of TFG at endoplasmic reticulum exit site (PubMed:27813252). Required for T-cell receptor-; Fas-; and glucocorticoid-induced apoptosis (By similarity). May mediate Ca(2+)-regulated signals along the death pathway: interaction with DAPK1 can accelerate apoptotic cell death by increasing caspase-3 activity (PubMed:16132846). Its role in apoptosis may however be indirect; as suggested by knockout experiments (By similarity). May inhibit KDR/VEGFR2-dependent angiogenesis; the function involves inhibition of VEGF-induced phosphorylation of the Akt signaling pathway (PubMed:21893193). In case of infection by HIV-1 virus; indirectly inhibits HIV-1 production by affecting viral Gag expression and distribution (PubMed:27784779).
- Gene Details:
- programmed cell death 6
- Molecular Weight:
- 48.9 kDa
- Protein Details:
- Programmed cell death protein 6
- Purity:
- Greater than 90% as determined by SDS-PAGE.
- Shipping Conditions:
- Blue Ice
- Source:
- E.coli
- Storage Conditions:
- -20Â[o]C or -80Â[o]C
- Supplier:
- Aviva Systems Biology
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Recombinant Proteins
- Manufacturer's Data Sheet:html_datasheet.php
