Recombinant human E3 ubiquitin- protein ligase MYLIP
Product Sizes
20ug
£348.00
OPCA00297-20UG
100ug
£500.00
OPCA00297-100UG
1mg
£1822.00
OPCA00297-1MG
About this Product
- SKU:
- OPCA00297
- Additional Names:
- band 4.1 superfamily member BZF1;cellular modulator of immune recognition (c-MIR);E3 ubiquitin ligase-inducible degrader of the low density lipoprotein receptor;E3 ubiquitin-protein ligase MYLIP;IDOL;inducible degrader of the LDL-receptor;MIR;Myosin regulatory light chain interacting protein;RING-type E3 ubiquitin transferase MYLIP.
- Extra Details:
- E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of myosin regulatory light chain (MRLC); LDLR; VLDLR and LRP8. Activity depends on E2 enzymes of the UBE2D family. Proteasomal degradation of MRLC leads to inhibit neurite outgrowth in presence of NGF by counteracting the stabilization of MRLC by saposin-like protein (CNPY2/MSAP) and reducing CNPY2-stimulated neurite outgrowth. Acts as a sterol-dependent inhibitor of cellular cholesterol uptake by mediating ubiquitination and subsequent degradation of LDLR.
- Gene Details:
- myosin regulatory light chain interacting protein
- Molecular Weight:
- 76.9 kDa
- Protein Details:
- E3 ubiquitin-protein ligase MYLIP
- Purity:
- Greater than 90% as determined by SDS-PAGE.
- Shipping Conditions:
- Blue Ice
- Source:
- E.coli
- Storage Conditions:
- -20Â[o]C or -80Â[o]C
- Supplier:
- Aviva Systems Biology
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Recombinant Proteins
- Manufacturer's Data Sheet:html_datasheet.php
